Six-months outcomes of a randomised trial of supportive text messaging for depression and comorbid alcohol use disorder
Six-months outcomes of a randomised trial of supportive text messaging for depression and comorbid alcohol use disorder
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DOI：
10.1016/j.jad.2013.05.058
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发表时间：
2013-10-01
影响因子：
6.6
通讯作者：
Farren, Conor K.
中科院分区：
文献类型：
--
作者：
Agyapong, Vincent I. O.;McLoughlin, Declan M.;Farren, Conor K.
背景和目的：我们之前报道过，每天发送两次支持性短信，持续三个月，有可能为抑郁症和共病酒精使用障碍（AUD）患者提供个性化支持。在这项研究中，我们报告了六个月的结果。方法：完成住院双重诊断治疗方案的DSM IV诊断为单极抑郁症和AUD的参与者（n=54）被随机分组，每天收到两次支持性短信（n=26）或每两周收到一次感谢短信（n=28），持续三个月。六个月时的主要结局指标是贝克抑郁量表（BDI-II）评分和累积戒断持续时间（CAD）。试验注册：NCT0137868。结果：与3个月时不同，干预组（n=24）与对照组（n=24） 6个月BDI-II评分差异无统计学意义；调整基线评分后分别为13.28 （SD=8.7）和15.08 (SD=11.37)， F(1,45)=0.192, p=0.66。短信组与对照组在CAD方面也无显著差异：84.14天（9.20）vs. 74.73天（28.97），t=1.422, df=41, p=0.16。干预组患者首次饮酒的天数明显高于对照组：119.9（47.7）比62.4 (44.9),t=2.99, df=22, p=0.01。局限性：该研究的局限性包括样本量小和可能失去盲法。结论：支持性短信干预的效果在患者接受干预后不会持续。(C) 2013 Elsevier B.V.版权所有
Background and objectives: We have previously reported that supportive text messages delivered twice daily for three months have the potential to provide personalised support for patients with depression and co-morbid Alcohol Use Disorder (AUD). In this study we report the six months outcomes.Methods: Participants (n=54) with a DSM IV diagnosis of unipolar depression and AUD who completed an in-patient dual diagnosis treatment programme were randomised to receive daily twice supportive text messages (n=26) or a fortnightly thank you text message (n=28) for three months. Primary outcome measures at six months were Beck's Depression Inventory (BDI-II) scores and Cumulative Abstinence Duration (CAD). Trial registration: NCT0137868.Results: Unlike at three months, there was no statistically significant difference in six months BDI-II scores between the intervention (n=24) and control (n=24) groups; 13.28 (SD=8.7) vs. 15.08 (SD=11.37) respectively after adjusting for the baseline scores, F(1, 45)=0.192, p=0.66. There was also no significant difference in CAD between the text message group and the control group: 84.14 clays (9.20) vs. 74.73 days (28.97), t=1.422, df=41, p=0.16. However, patients in the intervention group had significantly higher days to first drink compared to those in the control group: 119.9 (47.7) vs. 62.4 (44.9), t=2.99, df=22, p=0.01.Limitations: Limitations of the study include the small sample size and the potential for loss of rater blinding.Conclusion: The effects of supportive text message intervention were not sustained beyond the period that the patients were receiving the intervention. (C) 2013 Elsevier B.V. All rights reserved.