Frontostriatal systems comprising connections between ventral medial prefrontal cortex and nucleus accumbens subregions differentially regulate motor impulse control in rats
Frontostriatal systems comprising connections between ventral medial prefrontal cortex and nucleus accumbens subregions differentially regulate motor impulse control in rats
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DOI：
10.1007/s00213-014-3763-3
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发表时间：
2015-04-01
影响因子：
3.4
通讯作者：
Koch, Michael
中科院分区：
文献类型：
--
作者：
Feja, Malte;Koch, Michael
冲动控制的缺陷在几种神经精神疾病中普遍存在，这些疾病是基于额纹状体通讯受损。腹内侧前额叶皮层（vmPFC）和延髓核（NAc）是大鼠冲动控制的重要基底。NAc的核心和外壳被认为是差异参与，这表明vmPFC和特定NAc子区域之间的连接在冲动控制方面存在功能差异。通过对侧微量输注GABA（A）受体激动剂蝇蕈醇同时灭活大鼠的vmPFC和NAc核或壳，研究它们与五个脑区的冲动控制的相关性。选择系列反应时间任务（5-CSRTT）。断开vmPFC和NAc壳在抑制控制中产生特定的损伤，由显著增加的过早反应和增强的超时反应数量指示，与先前使用相同任务报道的vmPFC或NAc壳的双侧失活的效果非常相似。相比之下，断开的vmPFC和NAc核心只略有增加率的遗漏和延迟的奖励收集表明注意力和动机defictions.Our的研究结果扩展了以前的研究结果表明功能专业化的额纹状体网络和特定的vmPFC-NAc连接行为控制取决于NAc次区域的差异贡献。我们的结论是，调节大鼠的冲动控制需要一个完整的连接之间的vmPFC和NAC壳，而vmPFC-NAC核心的投影似乎是次要的。
Deficits in impulse control are prevalent in several neuropsychiatric disorders that are based on impaired frontostriatal communication. The ventral medial prefrontal cortex (vmPFC) and the nucleus accumbens (NAc) are key substrates of impulse control in rats. The NAc core and shell are considered to be differentially involved suggesting a functional distinction between the connections of the vmPFC and particular NAc subregions concerning impulse control.In the present study, simultaneous inactivation of the rats' vmPFC and NAc core or shell by contralateral microinfusion of the GABA(A) receptor agonist muscimol was used to investigate their relevance for impulse control in the five-choice serial reaction time task (5-CSRTT).Disconnection of the vmPFC and NAc shell produced specific impairments in inhibitory control, indicated by significantly increased premature responding and an enhanced number of time-out responses, closely resembling the effects of bilateral inactivation of either the vmPFC or NAc shell previously reported using the same task. In contrast, disconnection of the vmPFC and NAc core only slightly increased the rate of omissions and latency of reward collection indicating attentional and motivational deficits.Our results extend previous findings indicating the functional specialisation of frontostriatal networks and show a differential contribution of specific vmPFC-NAc connections to behavioural control depending on the NAc subregion. We conclude that the regulation of impulse control in rats requires an intact connection between the vmPFC and the NAc shell, while the vmPFC-NAc core projection seems to be of minor importance.