Chemical constituents of Calophyllum brasiliense.: 2.: Structure of three new coumarins and cancer chemopreventive activity of 4-substituted coumarins
Chemical constituents of Calophyllum brasiliense.: 2.: Structure of three new coumarins and cancer chemopreventive activity of 4-substituted coumarins
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DOI：
10.1021/np0203640
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发表时间：
2003-03-01
影响因子：
5.1
通讯作者：
Furukawa, H
中科院分区：
文献类型：
--
作者：
Ito, C;Itoigawa, M;Furukawa, H
继续我们的癌症化学预防剂的天然来源的搜索，我们检查了成分的红厚壳巴西干树皮。分离并鉴定了3个新的4-取代香豆素化合物，分别命名为brasimarins A（2），B（3）和C（4），沿着的还有11个已知的属于calanolides或inophyllums的香豆素化合物。我们还讨论了这些香豆素类化合物对Raji细胞中12-O-十四烷酰佛波醇-13-乙酸酯（TPA）诱导的EB病毒早期抗原（EBV-EA）活化的抑制作用。
Continuing our search for cancer chemopreventive agents from natural sources, we examined constituents of the stem bark of Calophyllum brasiliense. Three new 4-substituted coumarins named brasimarins A (2), B (3), and C (4) were isolated and characterized, along with 11 known coumarins belonging to the calanolides or inophyllums. We also discuss the inhibitory effects of these coumarins on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells.