Longitudinal clinical evaluation of adjunct minocycline in the treatment of chronic periodontitis
Longitudinal clinical evaluation of adjunct minocycline in the treatment of chronic periodontitis
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DOI：
10.1902/jop.2006.040409
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发表时间：
2006-02-01
影响因子：
4.3
通讯作者：
Pallos, Debora
中科院分区：
文献类型：
--
作者：
Cortelli, Jose Roberto;Rodrigues Querido, Silvia Maria;Pallos, Debora
背景资料：米诺环素联合彻底洁治和根面平整术（SRP）的临床获益已在多中心研究中进行了检查。本纵向调查的目的是评估的临床反应，以规模和根面平整结合使用局部交付米诺环素微球为720天的个人与先进的慢性periodontitis.Methods：共26个人年龄在26至69岁（平均：46.8 +/- 12.1岁）被列入本双盲随机临床试验。随机分组后，选择13名个体作为试验组（TG），并在基线和90、180和270天接受SRP+龈下米诺环素治疗，选择13名个体作为对照组（CG），并在相同时间点接受SRP+载体治疗。在每个受试者中选择两个探测深度（PD）>= 6 mm的同源部位。为了评估治疗后的临床反应，PD，菌斑指数（PI），牙龈指数（GI）进行了评估，在基线和90，180，270，360，720 d.Results：没有统计学差异，发现试验组和对照组之间的PD在不同的时间点。在第270天和第360天时，试验组的PD平均值降低幅度更大。TG和CG在90、180和720天时未观察到统计学差异（P < 0.05; Wilcoxon检验）。TG和CG之间关于PI和GI（P < 0.05;方差分析和t检验）在所有评估的timepoints.Conclusion：我们的研究结果表明，这两种疗法减少平均PD从90至360天，但是，SRP结合使用龈下米诺环素显示出更高的减少在270和360天后治疗。
Background: The clinical benefits of minocycline in combination with thorough scaling and root planing (SRP) have been examined in multicenter studies. The aim of this longitudinal investigation was to evaluate the clinical response to scaling and root planing combined with the use of locally delivered minocycline microspheres for 720 days in individuals with advanced chronic periodontitis.Methods: A total of 26 individuals aged 26 to 69 years (mean: 46.8 +/- 12.1 years) were included in this double-blind randomized clinical trial. After randomization, 13 individuals were selected for the test group (TG) and treated with SRP plus subgingival minocycline at baseline and 90, 180, and 270 days, and 13 individuals were selected for the control group (CG) and received SRP plus vehicle at the same time-points. Two homologous sites with probing depth (PD) >= 6 mm were chosen in each subject. To evaluate the clinical response after treatment, PD, plaque index (PI), and gingival index (GI) were assessed at baseline and 90, 180, 270, 360, and 720 days.Results: No statistical differences were found between test and control groups in relation to PD at the different timepoints. The mean values of PD demonstrated a higher reduction in the test group at 270 and 360 days. No statistical differences were observed at 90, 180, and 720 days between TG and CG (P < 0.05; Wilcoxon test). There were no statistically significant differences between TG and CG concerning PI and GI (P < 0.05; analysis of variance and t test) at all evaluated timepoints.Conclusion: Our findings demonstrated that both therapies reduced mean PD from 90 to 360 days; however, SRP combined with the use of subgingival minocycline showed a higher reduction at 270 and 360 days following therapy.