Translation of Precision Medicine Research Into Biomarker-Informed Care in Radiation Oncology.
Translation of Precision Medicine Research Into Biomarker-Informed Care in Radiation Oncology.
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DOI：
10.1016/j.semradonc.2021.09.001
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发表时间：
2022-01
影响因子：
3.5
通讯作者：
Scott JG
中科院分区：
文献类型：
--
作者：
Scarborough JA;Scott JG
在过去的几十年里，随着技术精度的提高，放射治疗向每个患者独特的解剖结构的输送得到了改善，放射肿瘤学的个性化医疗范围得到了极大的扩展。然而，对患者之间生物学异质性的考虑在很大程度上尚未转化为临床护理。在发现和验证生物标志物方面有无数有希望的进展，这些生物标志物可用于直接或间接改变放射治疗。直接地，生物标记物告知的护理可以改变治疗剂量或确定哪些患者将从放射治疗中受益最多，哪些患者可以安全地避免更积极的护理。间接地，各种生物标志物可以帮助选择最好的放射增敏化疗。将这些进展转化为临床实践将使放射肿瘤学进一步进入精准医学时代，根据患者独特的解剖学和生物学差异治疗患者。
The reach of personalized medicine in radiation oncology has expanded greatly over the past few decades as technical precision has improved the delivery of radiation to each patient’s unique anatomy. Yet, the consideration of biological heterogeneity between patients has largely not been translated to clinical care. There are innumerable promising advancements in the discovery and validation of biomarkers, which could be used to alter radiation therapy directly or indirectly. Directly, biomarker-informed care may alter treatment dose or identify patients who would benefit most from radiation therapy and who could safely avoid more aggressive care. Indirectly, a variety of biomarkers could assist with choosing the best radiosensitizing chemotherapies. The translation of these advancements into clinical practice will bring radiation oncology even further into the era of precision medicine, treating patients according to their unique anatomical and biological differences.
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DOI：
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影响因子：
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