Evaluation and comparison of coronary heart disease risk factor profiles of children in a country with developing economy.
Evaluation and comparison of coronary heart disease risk factor profiles of children in a country with developing economy.
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发表时间：
2004-07
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通讯作者：
K. Aziz;S. Aziz;A. Faruqui;N. Patel;H. Chagani;S. Hafeez;S. A. Ghuari;M. Memon;T. Ashraf;H. Sultana
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作者：
K. Aziz;S. Aziz;A. Faruqui;N. Patel;H. Chagani;S. Hafeez;S. A. Ghuari;M. Memon;T. Ashraf;H. Sultana
目的确定巴基斯坦城市社区高危因素的风险因素（RF）特征和患病率，并将其与巴基斯坦国家健康调查的RF特征和患病率进行比较。方法本研究包括400名家庭儿童的RF相关数据，作为Metroville健康研究（MHS）的一部分，该研究是美国国家心肺血液研究所（NHLBI）和巴基斯坦国家心血管疾病研究所合作的危险因素修正研究。纳入了389名5-17岁女孩和417名男孩的基线数据。PMRC的5067数据和NHANES III的10，252名美国儿童的调查数据用于与MHS进行比较。RF分析包括身高体重、收缩压、舒张压、体重指数和血清胆固醇。MHS和PMRC与美国之间的比较采用双尾学生t检验，高RF定义为超过美国标准的RF，并以百分比表示。结果城市儿童的RF因子谱比全国PMRC儿童的平均水平差。除了男孩和女孩的舒张压和PMRC男孩的SBP外，所有其他RF均低于美国儿童。城市Metroville社区的患病率较高，即，MHS与PMRC相比，PMRC代表国家平均数据。结论：通过比较PMRC和MHS的RF曲线，已介绍了巴基斯坦儿童的RF曲线，并证明了城市化的影响。巴基斯坦儿童的高血压已成为一个最重要的RF，需要紧急预防。
OBJECTIVE To define the risk factors (RF) profile and prevalence rates of high risk factors in an urban Pakistani community and compare it to the RF profile and prevalence rates of Pakistan National Health Survey. METHODS The present study included RF relevant data of 400 house hold children selected by open invitation as a part of Metroville Health Study (MHS), a risk factor modification study which was a cooperation between National Heart Lung Blood institute (NHLBI) USA and National Institute of Cardiovascular Diseases Pakistan. The base line data of 389 girls and 417 boys age 5-17 was included. PMRC data of 5067 and NHANES III survey data of 10,252 US children was used for comparison with MHS. RF analyzed were height weight, SBP, DBP, BMI and serum cholesterol. Comparisons between MHS and PMRC and US were made by using two tailed student t test and of high RF were defined as those exceeding US standards and expressed as percentages. RESULTS The RF factor profile of urban Metroville children was worse than the national average of PMRC children. Except for diastolic blood pressure in both boys and girls and SBP in PMRC boys, all other RF were less than US children. Prevalence rates were higher in urban Metroville community, i.e., MHS compared to the PMRC which represents national average data. CONCLUSION RF profile of Pakistani children has been presented and effect of urbanization demonstrated by comparing the PMRC and MHS RF profile. Hypertension in Pakistani children has emerged as a single most important RF requiring urgent prevention.