Cognitive impairment in epilepsy: the role of network abnormalities.
Cognitive impairment in epilepsy: the role of network abnormalities.
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DOI：
10.1684/epd.2015.0739
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发表时间：
2015-06
期刊：
影响因子：
--
通讯作者：
Holmes GL
中科院分区：
文献类型：
--
作者：
Holmes GL
癫痫患者面临的挑战远不止癫痫发作。癫痫的合并症很常见，对个体来说往往比癫痫发作本身更成问题。本文就认知障碍的病理生理机制作一综述。虽然癫痫的病因对认知有重要影响，但越来越多的证据表明，长时间或反复发作可引起或加剧认知障碍。信号通路和神经网络功能的改变在癫痫的病理生理和癫痫合并症中起着重要作用。然而，认知障碍的生物学基础可能不同于引起癫痫发作的病理生理过程。
The challenges to individuals with epilepsy extend far beyond the seizures. Co-morbidities in epilepsy are very common and are often more problematic to individuals than the seizures themselves. In this review, the pathophysiological mechanisms of cognitive impairment are discussed. While etiology of the epilepsy has a significant influence on cognition there is increasing evidence that prolonged or recurrent seizures can cause or exacerbate cognitive impairment. Alterations in signaling pathways and neuronal network function play a major role in both the pathophysiology of epilepsy and the epilepsy comorbidities. However, the biological underpinnings of cognitive impairment can be distinct from the pathophysiological processes that cause seizures.