Involvement of hippocampal metabotropic glutamate receptors in radial maze performance
Involvement of hippocampal metabotropic glutamate receptors in radial maze performance
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DOI：
10.1097/wnr.0b013e3280d9e880
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发表时间：
2007-05-07
期刊：
影响因子：
1.7
通讯作者：
Ichitani, Yukio
中科院分区：
文献类型：
--
作者：
Hayashi, Kazuko;Yoshihara, Toru;Ichitani, Yukio
We investigated the role of hippocampal metabotropic glutamate receptors in spatial learning and memory, using an eight-arm radial maze task. (S)-4-Carboxyphenylglycine, a group I metabotropic glutamate receptor antagonist, or trans-(+/-)-1-amino-(1S,3R)cyclopentanedicarboxylic acid, a broad-spectrum metabotropic glutamate receptor agonist, was administered into the dorsal hippocampus after rats had acquired the task. Both of these agents significantly impaired radial maze performance, suggesting a functional importance of hippocampal metabotropic glutamate receptors in spatial working memory.
