Organ and isotype distribution of plasma cells producing specific antibody after oral immunization: evidence for a generalized secretory immune system.
Organ and isotype distribution of plasma cells producing specific antibody after oral immunization: evidence for a generalized secretory immune system.
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口服免疫后产生特异性抗体的浆细胞的器官和同种型分布：广义分泌免疫系统的证据。
DOI：
10.4049/jimmunol.123.4.1705
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发表时间：
1979
影响因子：
4.4
通讯作者：
M. Lamm
中科院分区：
文献类型：
--
作者：
P. Weisz;M. Roux;M. Mcwilliams;J. M. Phillips;M. Lamm
小鼠经口服免疫诱导产生抗铁蛋白的IgA抗体。免疫荧光法在肠粘膜浆细胞以及其他分泌部位（如泌乳乳腺、唾液腺和呼吸道）检测到这些抗体。这一观察结果表明，通过肠道局部免疫的细胞可以回到远处的分泌部位。为了证实这一假设，淋巴细胞转移研究将肠系膜淋巴结（MN）和外周淋巴结（PN）细胞从口服免疫供者转移到非免疫受体。来自MN的IgA抗铁蛋白细胞归巢到外分泌靶点，而IgM和IgG抗铁蛋白细胞归巢到PN。这些发现总体上支持了一个普遍的和相互关联的分泌性免疫系统的概念。
Mice were induced to produce IgA antibodies against ferritin after oral immunization. Such antibodies were detected by immunofluorescence in plasma cells in the intestinal mucosa as well as in secretory sites located elsewhere, such as the lactating mammary gland, salivary gland, and respiratory tract. The observation suggested that cells immunized locally via the gut could home to distant secretory sites. To confirm this hypothesis, lymphocyte transfer studies were done with mesenteric node (MN) versus peripheral node (PN) cells from orally immunized donors into nonimmunized recipients. IgA anti-ferritin cells from MN homed to exocrine targets, whereas IgM and IgG anti-ferritin cells homed to PN. The findings overall support the concept of a generalized and interrelated secretory immune system.