Catheter-Based Treatment for Patients With Acute Ischemic Stroke Ineligible for Intravenous Thrombolysis
Catheter-Based Treatment for Patients With Acute Ischemic Stroke Ineligible for Intravenous Thrombolysis
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DOI：
10.1161/01.str.0000125711.94465.78
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发表时间：
2004-05
期刊：
影响因子：
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通讯作者：
S. Ramee;R. Subramanian;R. Felberg;Kevin L. McKinley;J. Jenkins;T. Collins;Robert C. Dawson;C. White
中科院分区：
文献类型：
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作者：
S. Ramee;R. Subramanian;R. Felberg;Kevin L. McKinley;J. Jenkins;T. Collins;Robert C. Dawson;C. White
背景和目的-我们介绍了我们的单中心经验，使用导管为基础的治疗急性缺血性卒中患者不适合静脉溶栓治疗。方法：对不适合静脉溶栓治疗的急性缺血性卒中患者采用紧急导管治疗的神经功能结局进行评估。结果-神经系统结局的非参数分析表明，在长期随访中，美国国立卫生研究院卒中量表（NIHSS）显示获益（P = 0.036）。分别有38%和56%的患者实现了日常活动的独立性和NIHSS改善≥4分。4例患者（25%）死亡，其中2例患者（12.5%）死于颅内出血。结论：导管治疗为不适合静脉溶栓治疗的急性缺血性卒中患者提供了一种有前景的治疗策略。
Background and Purpose— We present our single-center experience using catheter-based therapy for acute ischemic stroke patients who were not candidates for intravenous thrombolytic therapy. Methods— Neurologic outcomes were assessed in patients with acute ischemic stroke, ineligible for intravenous thrombolysis, treated with an emergent catheter-based therapy. Results— Nonparametric analysis of neurological outcomes demonstrated a benefit in National Institutes of Health Stroke Scale (NIHSS) at long-term follow-up (P = 0.036). Independence in daily activities and improvement in NIHSS of ≥4 points were achieved in 38% and 56% of patients, respectively. Four patients (25%) died, including 2 patients (12.5%) who died from intracranial hemorrhage. Conclusions— Catheter-based treatment offers a promising treatment strategy in patients with acute ischemic stroke ineligible for intravenous thrombolysis.