IQGAP1: insights into the function of a molecular puppeteer.
IQGAP1: insights into the function of a molecular puppeteer.
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IQGAP1：对分子木偶功能的洞察力。
DOI：
10.1016/j.molimm.2015.02.012
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发表时间：
2015-06
影响因子：
3.6
通讯作者：
Malarkannan S
中科院分区：
文献类型：
--
作者：
Abel AM;Schuldt KM;Rajasekaran K;Hwang D;Riese MJ;Rao S;Thakar MS;Malarkannan S
细胞内信号事件的时空组织对正常细胞功能至关重要。在对环境刺激的反应中，细胞利用高度组织的信号通路，这些信号通路受到多层调节。然而，协调这些复杂过程的分子机制仍然是一个谜。支架蛋白（支架蛋白）已成为信号通路的关键调节因子，其中许多在免疫细胞中具有良好的功能。IQGAP1是一种高度保守的细胞质支架蛋白，能够抑制、区隔和协调多种细胞类型中的多种信号通路。IQGAP1通过基于肌动蛋白/微管蛋白的细胞骨架重组，在细胞-细胞相互作用、细胞粘附和运动中发挥核心作用。也有证据表明IQGAP1是MAPK和Wnt/β-catenin信号通路的重要调节因子。本文就IQGAP1基因的细胞生物学和分子生物学研究进展进行综述。我们还描述了这种多效支架如何作为一个真正的分子木偶，并强调了未来研究IQGAP1在免疫细胞中的作用的重要性。
The intracellular spatiotemporal organization of signaling events is critical for normal cellular function. In response to environmental stimuli, cells utilize highly organized signaling pathways that are subject to multiple layers of regulation. However, the molecular mechanisms that coordinate these complex processes remain an enigma. Scaffolding proteins (scaffolins) have emerged as critical regulators of signaling pathways, many of which have well-described functions in immune cells. IQGAP1, a highly conserved cytoplasmic scaffold protein, is able to curb, compartmentalize, and coordinate multiple signaling pathways in a variety of cell types. IQGAP1 plays a central role in cell-cell interaction, cell adherence, and movement via actin/tubulin-based cytoskeletal reorganization. Evidence also implicates IQGAP1 as an essential regulator of the MAPK and Wnt/β-catenin signaling pathways. Here, we summarize the recent advances on the cellular and molecular biology of IQGAP1. We also describe how this pleiotropic scaffolin acts as a true molecular puppeteer, and highlight the significance of future research regarding the role of IQGAP1 in immune cells.
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影响因子：
64.5
作者：
Fukata, M;Watanabe, T;Kaibuchi, K
通讯作者：
Kaibuchi, K
DIA1和IQGAP1在细胞迁移和吞噬杯形成中相互作用。
影响因子：
7.8
作者：
Brandt, Dominique T.;Marion, Sabrina;Griffiths, Gareth;Watanabe, Takashi;Kaibuchi, Kozo;Grosse, Robert
通讯作者：
Grosse, Robert
影响因子：
2.5
作者：
Cupit, LD;Schmidt, VA;Bahou, WF
通讯作者：
Bahou, WF
DOI：
10.1073/pnas.0604236103
发表时间：
2006-07-05
影响因子：
11.1
作者：
Chen, Xi;Allan, David S. J.;Strominger, Jack L.
通讯作者：
Strominger, Jack L.
影响因子：
7.8
作者：
Adachi, H;Takahashi, Y;Sutoh, K
通讯作者：
Sutoh, K