Infection of human vascular endothelial cells by Rickettsia rickettsii.
Infection of human vascular endothelial cells by Rickettsia rickettsii.
复制标题
立克次氏体对人血管内皮细胞的感染。
DOI：
10.1093/infdis/149.2.201
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Bond,SB
中科院分区：
文献类型：
--
作者：
Silverman,DJ;Bond,SB
Rocky Mountain spotted fever is caused byRickettsia rickettsiian obligate intracellular bacterial parasite. The organism primarily attacks endothelial cells and occasionally attacks smooth-muscle cells of small blood vessels. An effective means of examining host-parasite interaction in Rocky Mountain spotted fever would be to use an in vitro model system with a host-cell type that is similar in structure and function to the putative target cell in human infections. Because human umbilical-vein endothelial cells in culture retain many, if not all, of their characteristic properties in vivo and because they also share many properties of capillary endothelium, the use of this endothelial cell system is appropriate in the study of the interaction betweenR rickettsiiand the cell that is principally parasitized in humans. Uptake by umbilical-vein endothelial-cell cultures ofR rickettsiiis dose dependent. The organism replicates in both the nucleus and cytoplasm of infected cells and exhibits early cell-to-cell spread without detectable host-cell injury.
