Clinical features of chronic urticaria in aging population
Clinical features of chronic urticaria in aging population
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DOI：
10.12932/ap0708
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发表时间：
2016-09-01
影响因子：
5
通讯作者：
Nuchkull, Piyavadee
中科院分区：
文献类型：
--
作者：
Chuamanochan, Mali;Kulthanan, Kanokvalai;Nuchkull, Piyavadee
背景：衰老患者与非衰老患者的皮肤疾病临床特征不同。然而，关注慢性荨麻疹（CU）在老年患者尤其是亚洲人群中的临床特征的数据仍然有限。目的：本研究旨在探讨亚洲人群老年和非老年患者CU的临床特点。方法：回顾性分析2000 - 2013年泰国玛希隆大学Siriraj医院皮肤科荨麻疹门诊就诊的1622例CU患者的病例记录。所有年龄大于60岁的CU患者均被招募。采用系统抽样方法，两倍于未衰老的CU患者入组。结果：1622例CU患者中，老年患者67例（4.1%）。从中招募了134名非老年CU患者。两组患者均以女性为主，老年组和非老年组分别占67.2%和77.6%。在两组中，CU的最常见原因是慢性自发性荨麻疹。衰老组自体血清皮肤试验阳性、抗甲状腺抗体阳性、抗核抗体阳性均高于非衰老组，差异无统计学意义。老年组的平均病程有缩短的趋势。结论：我们的研究表明，老年患者发生CU并不常见（4.1%）。与未衰老的CU患者相比，老年CU患者病程较短，自身抗体百分比较高，但差异无统计学意义。
Background: Different clinical features of skin diseases have been addressed between aging patients and non-aging patients. However, data focusing on the clinical features of chronic urticaria (CU) in aging patients especially in the Asian population are still limited.Objective: This study aimed to investigate the clinical characteristics of CU in aging and non-aging patients in the Asian population.Methods: Case records of 1622 CU patients attending the Urticaria Clinic, Department of Dermatology, Siriraj Hospital, Mahidol University, Thailand between 2000 and 2013 were retrospectively reviewed. All CU patients older than 60 years were recruited. Twice the number of CU patients who were non-aging were enrolled using a systematic sampling method.Results: Of the 1622 CU patients, 67 (4.1%) were aging patients. From these, 134 non-aging patients with CU were recruited. The majority of patients for both groups were female, with 67.2% and 77.6% of the aging and non-aging groups, respectively. In both groups, the most common cause of CU was chronic spontaneous urticaria. In the aging group, positive autologous serum skin test, anti-thyroid antibodies and antinuclear antibodies were found more commonly than in the non-aging group, without a statistically significant difference. The mean duration of the disease tended to be shorter in the aging group.Conclusion: Our study showed that CU in aging patients was uncommon (4.1%). Aging patients with CU seemed to have shorter disease duration and higher percentages of autoantibodies than non-aging patients with CU without a statistically significant difference.