Soft-tissue sarcomas and exposure to chemical substances: a case-referent study.
Soft-tissue sarcomas and exposure to chemical substances: a case-referent study.
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软组织肉瘤和化学物质暴露：病例参考研究。
DOI：
10.1136/oem.38.1.27
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
O. Axelson
中科院分区：
文献类型：
--
作者：
M. Eriksson;L. Hardell;N. Berg;T. Möller;O. Axelson
1977年，几名患者被发现患有软组织肉瘤，并且之前暴露于苯氧酸。这一临床观察导致正在进行的一项病例参照（病例对照）研究，该研究表明，接触化学上相关的苯氧基酸或氯酚，患这种肿瘤的风险增加约6倍。现在已经进行了进一步的软组织肉瘤病例相关研究，以证实这些早期发现，并获得有关不同苯氧酸影响的进一步信息。这项新的调查显示，在接触苯氧酸或氯酚后，软组织肉瘤的风险增加了相同的幅度，但这种风险也与接触不含杂质的苯氧酸有关，如多氯二苯并二恶英和二苯并呋喃。
In 1977 several patients were seen with soft-tissue sarcomas and previous exposure to phenoxy acids. This clinical observation resulted in a cases-referent (case-control) study being undertaken which showed that exposure to phenoxy acids or chlorophenols, which are chemically related, gave a roughly six-fold increase in the risk for this type of tumour. A further case-referent study of soft-tissue sarcomas has now been performed to confirm these earlier findings and also to obtain further information on the effects of different phenoxy acids. This new investigation gave an increase of the same magnitude in the risk for soft-tissue sarcomas after exposure to phenoxy acids or chlorophenols, but this risk related also to exposure to phenoxy acids free from impurities, such as polychlorinated dibenzodioxins and dibenzofurans.