CONCISE SYNTHESIS OF YINGZHAOSU-C AND EPI-YINGZHAOSU-C BY PEROXYL RADICAL CYCLIZATION - ASSIGNMENT OF RELATIVE CONFIGURATION
CONCISE SYNTHESIS OF YINGZHAOSU-C AND EPI-YINGZHAOSU-C BY PEROXYL RADICAL CYCLIZATION - ASSIGNMENT OF RELATIVE CONFIGURATION
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DOI：
10.1016/0040-4039(95)00714-n
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发表时间：
1995-06-12
影响因子：
1.8
通讯作者：
FRECHETTE, Y
中科院分区：
文献类型：
--
作者：
BOUKOUVALAS, J;POULIOT, R;FRECHETTE, Y
采用串列过氧自由基环化-包氧法制备了抗疟药过氧化物映照素C及其非对映异构体映照素C。根据非对映异构体(2)和(3)及其前体(8)和(9)的NMR数据，确定映照素C的相对构型为顺式(3)。
The antimalarial peroxide yingzhaosu C and its diastereoisomer (epi-yingzhaosu C) have been synthesized by means of tandem peroxyl radical cyclization-oxygen entrapment. The relative configuration of yingzhaosu C is assigned as cis (3) on account of NMR data for both diastereoisomers, (2) and (3), and their precursors (8) and (9).