Impaired atrial electromechanical function and atrial fibrillation promotion in alloxan-induced diabetic rabbits
Impaired atrial electromechanical function and atrial fibrillation promotion in alloxan-induced diabetic rabbits
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四氧嘧啶诱发糖尿病兔的心房机电功能受损和心房颤动的促进
DOI：
10.5603/cj.2013.0010
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发表时间：
2013-01-01
影响因子：
2.9
通讯作者：
Li, Guangping
中科院分区：
文献类型：
--
作者：
Fu, Huaying;Liu, Changle;Li, Guangping
背景：糖尿病（DM）是心房颤动（AF）的独立危险因素。然而，其潜在机制仍不清楚。本研究旨在探讨四氧嘧啶糖尿病兔心房电机械功能、心房电生理变化及房颤诱发因素。方法：采用组织多普勒成像技术，对8只四氧嘧啶糖尿病兔和8只正常对照兔的心房电机械功能进行了研究。采用离体Langendorff灌流兔心脏，测定心房不应期（AERP）及其离散度（AERPD）、心房传导时间（TACT）和心房纤颤易损性，用双极红染色法观察心房间质纤维化程度。糖尿病兔AERPD增加，TACT延长。糖尿病组房颤发生率明显高于对照组（618 vs.118，p < 0.05）。DM组间质纤维化程度较轻（<0.01）。相关性分析显示，右房壁Pastart、Pa '-peak间期（Papeak）、总电机械活动（特马）、左房侧壁Papeak、特马、左房后壁特马、IACT与心房纤维化面积相关。（Cardiol J 2013; 20，1：59-67）
Background: Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). However, the underlying mechanisms are still not clearly elucidated. The aim of this study was to evaluate the atrial electromechanical function, atrial electrophysiological changes and AF inducibility in alloxan-induced diabetic rabbits.Methods: In 8 alloxan-induced diabetic rabbits and 8 controls, we evaluated atrial electromechanical function by tissue Doppler imaging. Isolated Langendorff-perfused rabbit hearts were prepared to measure atrial refractory effective period (AERP) and its dispersion (AERPD), interatrial conduction time (TACT) and vulnerability to AF Atrial interstitial fibrosis was evaluated by Sirius-Red staining.Results: Compared with controls, left atrial lateral wall Pa'-start interval (Pastart) and right atrial wall Pastart were increased in diabetic rabbits. AERPD was increased and TACT was prolonged in diabetic rabbits. Inducibility of AF in diabetic group was significant higher than controls (618 vs. 118, p < 0.05). Extensive interstitial fibrosis was observed in the DM group < 0 01). Correlation analysis showed that right atrial wall Pastart, Pa'-peak interval (Papeak) and total electromechanical activity (TEMA); left atrial lateral wall Papeak and TEMA, left atrial posterior wall TEMA, and IACT were correlated with atrial areas of fibrosis.Conclusions: Atrial electromechanical function is impaired in diabetic rabbits, and is associated with atrial fibrosis and interatrial electrical conduction delay. (Cardiol J 2013; 20, 1: 59-67)