Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
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DOI：
10.1038/nature02789
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发表时间：
2004-08-05
期刊：
影响因子：
64.8
通讯作者：
Sinclair, D
中科院分区：
文献类型：
--
作者：
Wood, JG;Rogina, B;Sinclair, D
热量限制延长了许多物种的寿命。在出芽酵母酿酒酵母中，这种作用需要Sir2（参考文献1），Sir2是NAD（+）依赖性脱乙酰酶sirtuin家族的一员（2,3）。Sirtuin激活化合物（STACs）可以促进人类细胞的存活并延长酵母的复制寿命(4)。本研究表明，白藜芦醇和其他STACs可以激活秀丽隐杆线虫和黑腹果蝇的sirtuins，并在不降低繁殖力的情况下延长这些动物的寿命。寿命的延长依赖于功能性Sir2，而当营养受到限制时则没有观察到寿命的延长。综上所述，这些数据表明STACs通过可能与热量限制有关的机制减缓了后生动物的衰老。
Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD(+)-dependent deacetylases(2,3). Sirtuin activating compounds (STACs) can promote the survival of human cells and extend the replicative lifespan of yeast(4). Here we show that resveratrol and other STACs activate sirtuins from Caenorhabditis elegans and Drosophila melanogaster, and extend the lifespan of these animals without reducing fecundity. Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted. Together these data indicate that STACs slow metazoan ageing by mechanisms that may be related to caloric restriction.