Lipoproteins and atherosclerosis. A look back and a look ahead.
Lipoproteins and atherosclerosis. A look back and a look ahead.
复制标题
脂蛋白和动脉粥样硬化。
DOI：
10.1161/01.atv.3.4.283
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Steinberg,D
中科院分区：
文献类型：
--
作者：
Steinberg,D
我很荣幸能主持1982年的达夫纪念讲座。首先，我应该承认，多年来，在动脉粥样硬化研究领域，我一直感觉自己有点像一个伪装者。可以肯定的是，我一直非常参与脂类和脂蛋白的研究，因此，在脂蛋白参与动脉粥样硬化形成的程度上，我可以证明我参加理事会的议事程序是合理的。但G·莱曼·达夫本人的声音让我感到不安。在1951年，他与我们杰出的前任主席之一加德纳·麦克米兰(Gardner McMillan)一起撰写的一篇经典评论中，他提到了对脂类假说过于热情的拥护者，如下所述：“这一观点[脂类假说]变得如此流行，以至于最近文献的普通读者可能会怀疑，是否有些作者认为动脉粥样硬化是如此独立于血管壁的基质，以至于它可能在没有血管本身的情况下发生。”1我希望我不是那些作者中的一员，但你可以看到，如果我在一场达夫演讲中没有出现动脉壁细胞，我会感到不舒服。我可以向你保证，它们会出现--甚至是一条完整的动脉--我松了一口气。
It is an honor and privilege to present the 1982 Duff Memorial Lecture. I should start by confessing that for some years I have felt a bit like a pretender in the field of atherosclerosis research. To be sure, I have been very much involved in lipid and lipoprotein research and so, to the extent that lipoproteins are involved in atherogenesis, I could justify my participation in the proceedings of the Council. But the voice of G. Lyman Duff himself made me uneasy. In a classic review he wrote in 1951 together with one of our outstanding past Chairmen, Gardner McMillan, he referred to overly enthusiastic champions of the lipid hypothesis as follows:" So popular has this view [the lipid hypothesis] become that the casual reader of recent literature might wonder whether some authors conceive of an atherosclerosis so independent of the substrate of the vessel wall that it may occur in the absence of the blood vessels themselves." 1 I hope that I am not one of those authors, but you can see that I would have felt uncomfortable presenting a Duff Lecture in which the cells of the artery wall did not make an appearance. I am relieved to be able to assure you that they will appear—even an intact artery.