Bioactive glass-polymer materials for controlled release of ibuprofen
Bioactive glass-polymer materials for controlled release of ibuprofen
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DOI：
10.1016/s0142-9612(03)00279-5
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发表时间：
2003-10-01
期刊：
影响因子：
14
通讯作者：
Vallet-Regí, M
中科院分区：
文献类型：
--
作者：
de Guevara-Fernández, SL;Ragel, CV;Vallet-Regí, M
研究了由SiO_2-CaO-P_2O_5生物活性玻璃、聚L-乳酸和聚甲基丙烯酸甲酯组成的样品中布洛芬(1B)的释放。数据显示，当这些多相材料浸泡在模拟体液(SBF)中时，在最初的8小时内，抗炎药物快速释放。在SBF中浸泡不同时间前后的样品分析表明，材料表面生长了类磷灰石。113的释放速率与这一层的生长动力学有关，即当材料不含可生物降解的聚合物聚乳酸时，释放速度较慢。另一方面，不同的113和/或玻璃含量不影响这些材料的体外行为。(C)2003爱思唯尔科学有限公司。保留所有权利。
The ibuprofen (1B) release from samples composed by SiO2-CaO-P2O5 bioactive glass, poly-L-lactic acid (PLA), and polymethylmethacrylate (PMMA) has been studied. Data showed a fast anti-inflammatory drug release during the first 8 h when these polyphasic materials are soaked in simulated body fluid (SBF). The analysis of the samples before and after different soaking periods in SBF demonstrates the growth of an apatite-like layer on the materials surface. The 113 release rate is related with the growth kinetics of this layer, that is slower when the materials do not contain the biodegradable polymer PLA. On the other hand, different 113 and/or glass contents do not affect the in vitro behavior of these materials. (C) 2003 Elsevier Science Ltd. All rights reserved.