Cervicography for triage of women with mildly abnormal cervical cytology results.
Cervicography for triage of women with mildly abnormal cervical cytology results.
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DOI：
10.1067/mob.2001.117485
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发表时间：
2001-10
影响因子：
9.8
通讯作者：
D. Ferris;Mark Schiffman;Mark Schiffman;M. Litaker;M. Litaker
中科院分区：
文献类型：
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作者：
D. Ferris;Mark Schiffman;Mark Schiffman;M. Litaker;M. Litaker
目的 评估参与美国国家癌症研究所意义未明的多中心非典型鳞状细胞和低级别鳞状上皮内病变分类研究 (ALTS) 的女性中宫颈造影检测宫颈癌前驱病变的敏感性和特异性。研究设计 3134 名女性获得了宫颈照片，这些女性转诊巴氏涂片诊断为意义未明的非典型鳞状细胞或低度鳞状上皮内病变。使用宫颈上皮内瘤变 (CIN) 2 和 CIN 3 疾病终点比较宫颈照片和宫颈组织学结果。结果 在 3134 名女性中，444 名的组织学结果大于或等于 CIN 2，222 名的组织学结果为 CIN 3。使用大于或等于非典型阈值进行宫颈造影解读时，检测大于或等于 CIN 3 的敏感性、特异性以及阳性和阴性预测值分别为 79.3%、61.0%、13.4% 和 97.5%。与 35 岁或以上女性相比，宫颈造影对于检测 35 岁以下女性的 CIN 3 更敏感（80.8% 比 57.1%），但特异性较差（55.7% 比 81.8%）。结论 对于具有未确定意义的非典型鳞状细胞和巴氏涂片结果的低度鳞状上皮内病变的女性，宫颈造影在检测 CIN 2 或 CIN 3 方面功能中等。年轻女性的宫颈造影敏感性更好。
OBJECTIVE To estimate the sensitivity and specificity of cervicography in detecting cervical cancer precursor lesions in women participating in the National Cancer Institute's multicenter atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion triage study (ALTS). STUDY DESIGN Cervigrams were obtained from 3134 women with a referral Papanicolaou smear diagnosis of atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion. Cervigram and cervical histology results were compared by using cervical intraepithelial neoplasia (CIN) 2 and CIN 3 disease end points. RESULTS Of 3134 women, 444 had histologic findings of more than or equal to CIN 2 and 222 had CIN 3. Cervicography interpretation by using a threshold of greater than or equal to atypical had a sensitivity, specificity, and positive and negative predictive values of 79.3%, 61.0%, 13.4%, and 97.5%, respectively, for detecting greater than or equal to CIN 3. Cervicography was more sensitive (80.8% vs 57.1%), but less specific (55.7% vs 81.8%), for detecting CIN 3 in women younger than 35 years compared with women 35 years or older, respectively. CONCLUSIONS Cervicography functioned moderately well at detecting CIN 2 or CIN 3 in women with atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion Papanicolau smear results. Cervigram sensitivity was better for younger women.