TUMOR NECROSIS FACTOR IN SYNOVIAL EXUDATES
TUMOR NECROSIS FACTOR IN SYNOVIAL EXUDATES
复制标题
DOI：
10.1136/ard.47.9.768
复制
发表时间：
1988-09-01
影响因子：
27.4
通讯作者：
DUFF, GW
中科院分区：
文献类型：
--
作者：
DIGIOVINE, FS;NUKI, G;DUFF, GW
肿瘤坏死因子（TNF）的作用包括骨和软骨的再吸收，表明在关节炎的发病机制中具有潜在的作用。TNF活性在137例不同风湿性疾病患者的滑液中寻找。在L929生物测定中检测未分级样品。在44份样本中，有13份（30%）出现了被TNF α单克隆抗体中和的显著TNF活性。升高的TNF水平与任何特定疾病类型或常规实验室炎症标志物无关，但与骨关节炎的病程有关。在关节炎患者的症状关节中发现具有生物活性的TNF支持了它可能有助于慢性风湿性疾病关节损伤的发病机制的想法。
The actions of tumour necrosis factor (TNF) include resorption of bone and cartilage, suggesting a potential role in the pathogenesis of arthritis. TNF activity was looked for in synovial fluids from 137 patients with different rheumatic diseases. Unfractionated samples were tested in the L929 bioassay. Significant TNF activity that was neutralised by monoclonal antibody to TNF alpha occurred in 13 (30%) of 44 samples. Raised TNF levels were not associated with any particular disease type or routine laboratory markers of inflammation but were related to disease duration in osteoarthritis. The finding of biologically active TNF in symptomatic joints of arthritic patients supports the idea that it may contribute to the pathogenesis of joint damage in chronic rheumatic diseases.