The Iowa 500: affective disorder in relatives of manic and depressed patients.
The Iowa 500: affective disorder in relatives of manic and depressed patients.
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爱荷华 500：躁狂症和抑郁症患者亲属的情感障碍。
DOI：
10.1176/ajp.139.2.209
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
R. Crowe
中科院分区：
文献类型：
--
作者：
G. Winokur;M. Tsuang;R. Crowe
大约10%的住院单极抑郁症患者最终变成了双相抑郁症。采用盲法评估来自患者（N = 485）和一级亲属（N = 2803）访谈和医院记录的数据，作者发现双相先证者和单极先证者在其家庭中有更多的情感性疾病。虽然双相先证者比单极先证者有更多的亲属患有双相疾病，但双相先证者和单极先证者的亲属患情感性疾病的风险差异不显著。一般来说，女性抑郁症亲属多于男性抑郁症亲属，但双相情感障碍亲属中男性和女性人数相等，这表明双相情感障碍先证者家庭中的疾病存在异质性。
About 10% of hospitalized unipolar depressed patients ultimately became bipolar. Using a blind protocol to assess data from patient (N = 485) and first-degree relative (N = 2,803) interviews and hospital records, the authors found that bipolar probands and unipolar probands had more affective illness in their families than did control subjects. Although more relatives of bipolar probands than of unipolar probands had bipolar illness, the difference in risk for affective illness between relatives of bipolar probands and of unipolar probands was not significant. In general there were more female than male depressed relatives, bit the equal numbers of men and women among bipolar relatives suggest heterogeneity of illness within the families of bipolar probands.