Barrett's esophagus: genetic and cell changes.
Barrett's esophagus: genetic and cell changes.
复制标题
巴雷特食管：遗传和细胞变化。
DOI：
10.1111/j.1749-6632.2011.06043.x
复制
发表时间：
2011
影响因子：
5.2
通讯作者：
Schneid
中科院分区：
文献类型：
--
作者：
Souza,RhondaF;Freschi,Giancarlo;Taddei,Antonio;Ringressi,MariaNovella;Bechi,Paolo;Castiglione,Francesca;RossiDegl'Innocenti,Duccio;Triadafilopoulos,George;Wang,JeanS;Chang,AndrewC;Barr,Hugh;Bajpai,Manisha;Das,KironM;Schneid
以下包括关于如何更好地了解Barrett食管（BE）患者的遗传密码，GERD诱导的尾部同源盒食管表达的机制以及Barrett化生的发展的评论，包括基质基因在肿瘤发生中的作用。从非肿瘤细胞系的体外模型中已经学到了更多的经验教训，但BE衍生细胞系的预期存在局限性。讨论的其他主题包括克隆多样性在巴雷特食管;肽阵列的应用，粘膜化生的临床样本;增殖和凋亡的巴雷特细胞系;肿瘤的组织生物标志物;和转录因子与BE。
The following includes commentaries on how genetic code of Barrett's esophagus (BE) patients, the mechanisms for GERD‐induced esophageal expression of caudal homeobox, and the development of Barrett's metaplasia are increasingly better known, including the role of stromal genes in oncogenesis. Additional lessons have been learned fromin vitromodels in nonneoplastic cell lines, yet there are limitations to what can be expected from BE‐derived cell lines. Other topics discussed include clonal diversity in Barrett's esophagus; the application of peptide arrays to clinical samples of metaplastic mucosa; proliferation and apoptosis of Barrett's cell lines; tissue biomarkers for neoplasia; and transcription factors associated with BE.