Hyperthermia for the treatment of articular cartilage with osteoarthritis
Hyperthermia for the treatment of articular cartilage with osteoarthritis
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DOI：
10.3109/02656730903107519
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发表时间：
2009-01
影响因子：
3.1
通讯作者：
Kenji A. Takahashi;H. Tonomura;Y. Arai;R. Terauchi;K. Honjo;N. Hiraoka;T. Hojo;Taisuke Kunitomo;T. Kubo
中科院分区：
文献类型：
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作者：
Kenji A. Takahashi;H. Tonomura;Y. Arai;R. Terauchi;K. Honjo;N. Hiraoka;T. Hojo;Taisuke Kunitomo;T. Kubo
骨关节炎（OA）是老年人群中最常见的肌肉骨骼疾病之一。 OA的特征是关节软骨中细胞外基质的逐渐丧失。当关节破坏严重时，只能通过人工关节置换来治疗骨关节炎。因此，最好采取简单、有效的保守疗法，在早期阶段抑制OA的进展。热休克蛋白70（Hsp70）对软骨有保护作用，抑制软骨细胞凋亡。微波对关节的热刺激可以增加软骨细胞中Hsp70的表达，同时Hsp70的表达部分增强软骨的基质代谢。这些发现表明热疗可以积极应用于OA的治疗。因此，热疗有望成为一种廉价且侵入性较小的 OA 保守疗法。
Osteoarthritis (OA) is one of the most frequent musculoskeletal disorders in the elderly population. OA is characterised by a gradual loss of extracellular matrix in the articular cartilage of joints. OA can only be managed by artificial joint replacement when joint destruction becomes severe. Therefore, it is preferable to administer conservative therapy that is easy, simple and effective in inhibiting OA progression at the early stage. Heat shock protein 70 (Hsp70) has a protective effect on the cartilage and inhibits the apoptosis of chondrocytes. Heat stimulation by microwave to the joints can increase Hsp70 expression in chondrocytes, and at the same time, Hsp70 expression partially enhances matrix metabolism of the cartilage. These findings suggest that hyperthermia can be positively applied to the treatment of OA. Hyperthermia is therefore expected to be an inexpensive and less-invasive conservative therapy for OA.