Clinical Significance of Integrin Subunit Beta 4 in Head and Neck Squamous Cell Carcinoma
Clinical Significance of Integrin Subunit Beta 4 in Head and Neck Squamous Cell Carcinoma
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DOI：
10.1089/cbr.2020.3943
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发表时间：
2020-11-11
影响因子：
3.4
通讯作者：
Wei, Hong-Yu
中科院分区：
文献类型：
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作者：
Li, Guo-Sheng;Hou, Wei;Wei, Hong-Yu
背景：头颈鳞状细胞癌 (HNSCC) 中整合素亚基 β 4 (ITGB4) 的表达水平和临床意义尚不清楚。 材料和方法：通过基于多个来源的基因芯片、RNA-seq 和免疫组织化学数据 (n = 2330) 计算标准均差 (SMD) 来评估 ITGB4 在 HNSCC 组织中的表达。使用受试者工作特征（ROC）曲线来检测ITGB4区分HNSCC和非HNSCC样本的能力。通过计算SMD来评估ITGB4表达水平与临床参数之间的关系。结果：mRNA和蛋白水平的相同结果表明ITGB4在HNSCC组织中显着上调。进一步的 ROC 曲线显示 ITGB4 可以区分 HNSCC 和非 HNSCC 样本。 HNSCC 中 ITGB4 的遗传改变分析表明，HNSCC 中 ITGB4 的过度表达可能不是由于 ITGB4 的遗传改变所致。此外，ITGB4过表达水平可能与临床T分期相关。结论：根据我们的研究，ITGB4可能在HNSCC的发生中发挥重要作用，其潜在的诊断价值值得未来进一步探索。
Background: The expression level and clinical significance of integrin subunit beta 4 (ITGB4) in head and neck squamous cell carcinoma (HNSCC) remain unclear.Materials and Methods: Expression of ITGB4 in HNSCC tissues were evaluated by calculating standard mean differences (SMDs) based on gene chips, RNA-seq, and immunohistochemistry data (n = 2330) from multiple sources. Receiver operating characteristic (ROC) curves were used to detect the ability of ITGB4 to distinguish HNSCC from non-HNSCC samples. The relationship between the expression level of ITGB4 and clinical parameters was evaluated by calculating SMDs.Results: Identical results of mRNA and protein levels indicated remarkable up-expression of ITGB4 in HNSCC tissues. Further ROC curves showed that ITGB4 could distinguish HNSCC from non-HNSCC samples. Genetic alteration analysis of ITGB4 in HNSCC indicated that overexpression of ITGB4 in HNSCC was likely not owing to genetic alteration of ITGB4. Moreover, ITGB4 overexpression level may be correlated with clinical T stage.Conclusion: ITGB4 likely plays an essential role in HNSCC occurrence based on our study and its potential diagnostic value is worthy of further exploration in the future.