Reward-learning and the novelty-seeking personality: a between- and within-subjects study of the effects of dopamine agonists on young Parkinsons patients
Reward-learning and the novelty-seeking personality: a between- and within-subjects study of the effects of dopamine agonists on young Parkinsons patients
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DOI：
10.1093/brain/awp094
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发表时间：
2009-09-01
期刊：
影响因子：
14.5
通讯作者：
Gluck, Mark A.
中科院分区：
文献类型：
--
作者：
Bodi, Nikoletta;Keri, Szabolcs;Gluck, Mark A.
帕金森病的特征在于投射到纹状体的多巴胺能通路的变性。这些途径与奖励预测有关。在这项研究中，我们调查了奖励和惩罚的处理在年轻的，从未用药的帕金森病患者，最近接受多巴胺受体激动剂普拉克索和罗匹尼罗和健康对照药物治疗的患者。从未接受过药物治疗的患者在接受多巴胺激动剂治疗12周后也进行了重新评估。奖励和惩罚的处理进行了评估的反馈为基础的概率分类任务。人格特征采用气质和性格量表测量。结果显示，从未接受药物治疗的帕金森病患者在奖励处理和新奇寻求方面表现出选择性缺陷，这些缺陷可以通过多巴胺受体激动剂得到纠正。这些药物扰乱了惩罚过程。此外，多巴胺激动剂增加了奖励处理和新奇寻求之间的相关性，而这些药物降低了惩罚处理和伤害避免之间的相关性。我们的研究发现，年轻帕金森病患者服用多巴胺受体激动剂会导致新奇寻求增加，奖励处理增强，惩罚处理减少，这可能会揭示冲动控制障碍的认知和个性基础，这是多巴胺受体激动剂治疗帕金森病患者的副作用。
Parkinsons disease is characterized by the degeneration of dopaminergic pathways projecting to the striatum. These pathways are implicated in reward prediction. In this study, we investigated reward and punishment processing in young, never-medicated Parkinsons disease patients, recently medicated patients receiving the dopamine receptor agonists pramipexole and ropinirole and healthy controls. The never-medicated patients were also re-evaluated after 12 weeks of treatment with dopamine agonists. Reward and punishment processing was assessed by a feedback-based probabilistic classification task. Personality characteristics were measured by the temperament and character inventory. Results revealed that never-medicated patients with Parkinsons disease showed selective deficits on reward processing and novelty seeking, which were remediated by dopamine agonists. These medications disrupted punishment processing. In addition, dopamine agonists increased the correlation between reward processing and novelty seeking, whereas these drugs decreased the correlation between punishment processing and harm avoidance. Our finding that dopamine agonist administration in young patients with Parkinsons disease resulted in increased novelty seeking, enhanced reward processing, and decreased punishment processing may shed light on the cognitive and personality bases of the impulse control disorders, which arise as side-effects of dopamine agonist therapy in some Parkinsons disease patients.