Manganese (Mn) and iron (Fe): interdependency of transport and regulation.
Manganese (Mn) and iron (Fe): interdependency of transport and regulation.
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DOI：
10.1007/s12640-009-9130-1
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发表时间：
2010-08
影响因子：
3.7
通讯作者：
Aschner M
中科院分区：
文献类型：
--
作者：
Fitsanakis VA;Zhang N;Garcia S;Aschner M
锰(Mn)和铁(Fe)是过渡金属，对生物的适当生长、发育、功能和维持至关重要。由于它们在化学上的相似性，在从细菌到哺乳动物的各种生物体中，它们共享和竞争许多蛋白质转运蛋白，例如二价金属转运蛋白-1。因此，在低铁条件下，出现了异常的锰积累。相反，当锰浓度改变时，铁和其他过渡金属的动态平衡和沉积被破坏。我们的实验室在大鼠身上进行了一系列研究，涉及怀孕的母鼠、新生儿和围产期的幼崽，以及成年动物。动物暴露在不同浓度的饲料铁和/或锰中，检测蛋白质转运蛋白的表达、血中锰和铁的浓度、脑过渡金属的浓度以及脑组织的沉积模式。因此，我们已经证明了锰和铁运输的相互依赖性的重要性，并在几项纵向研究中确定了脑中金属的浓度。本综述的目的是全面审查这些研究，并强调在设计未来与过渡金属水平的饮食或环境变化有关的研究时，监测锰和铁的沉积和积累的重要性。最后，这篇综述将提供目前研究界正在研究的与铁和锰的调节和运输有关的各种转运蛋白的信息。
Manganese (Mn) and iron (Fe) are transition metals that are crucial to the appropriate growth, development, function, and maintenance of biological organisms. Because of their chemical similarity, in organisms ranging from bacteria to mammals they share and compete for many protein transporters, such as the divalent metal transporter-1. As such, during conditions of low Fe, abnormal Mn accumulation occurs. Conversely, when Mn concentrations are altered, the homeostasis and deposition of Fe and other transition metals are disrupted. Our lab has undertaken a series of studies in rats involving pregnant dams, neo- and perinatal pups, and adult animals. Animals were exposed to various concentrations of dietary Fe and/or Mn, and protein transporter expression, blood Mn and Fe concentrations, brain transition metal concentrations, and temporal brain deposition patterns were examined. As a result, we have demonstrated the importance of the interdependence of the transport of Mn and Fe, and established brain metal concentrations in several longitudinal studies. The purpose of this review is to examine these studies in their entirety and highlight the importance of monitoring the deposition and accumulation of both Mn and Fe when designing future studies related to either dietary or environmental changes in transition metal levels. Finally, this review will provide information about various transport proteins currently under investigation in the research community related to Fe and Mn regulation and transport.
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影响因子：
3.4
作者：
Bowler, Rosemarie M.;Koller, William;Schulz, Paul E.
通讯作者：
Schulz, Paul E.
影响因子：
3.8
作者：
Anderson, Joel G.;Cooney, Paula T.;Erikson, Keith M.
通讯作者：
Erikson, Keith M.
影响因子：
4.1
作者：
Brown, DR;Wong, BS;Jones, IM
通讯作者：
Jones, IM
DOI：
10.1007/s003600050085
发表时间：
1997-07-01
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY
影响因子：
--
作者：
Chua, ACG;Morgan, EH
通讯作者：
Morgan, EH
影响因子：
3.4
作者：
Choi, Christopher J.;Kanthasamy, Arthi;Kanthasamy, Anumantha G.
通讯作者：
Kanthasamy, Anumantha G.