Chemoenzymatic synthesis of triazole-linked glycopeptides
Chemoenzymatic synthesis of triazole-linked glycopeptides
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DOI：
10.1055/s-2006-942509
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发表时间：
2006-09-18
影响因子：
2.6
通讯作者：
Rutjes, Floris P. J. T.
中科院分区：
文献类型：
--
作者：
Groothuys, Stan;Kuijpers, Brian H. M.;Rutjes, Floris P. J. T.
Triazole-linked glycopeptides are prepared by C-terminal elongation of glycoamino acids with protemogenic amino acids following a chemical or enzymatic coupling protocol. Two orthogonal routes for a chemoenzymatic strategy were explored, involving a click-reaction before amide bond formation or in reverse order. It was found that enzymatic peptide coupling under the influence of alcalase proceeds cleanly and in high yields, while the resulting dipeptides can be efficiently clicked to acetylene- or azide-containing sugars.
