Changes in Corticospinal Excitability and Motor Control During Cerebellar Transcranial Direct Current Stimulation in Healthy Individuals
Changes in Corticospinal Excitability and Motor Control During Cerebellar Transcranial Direct Current Stimulation in Healthy Individuals
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DOI：
10.1007/s12311-022-01469-2
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发表时间：
2022-09
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影响因子：
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通讯作者：
Keita Takano;Natsuki Katagiri;Takatsugu Sato;Masafumi Jin;Tadaki Koseki;D. Kudo;Kaito Yoshida;S. Tanabe;M. Tsujikawa;K. Kondo;Tomofumi Yamaguchi
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作者：
Keita Takano;Natsuki Katagiri;Takatsugu Sato;Masafumi Jin;Tadaki Koseki;D. Kudo;Kaito Yoshida;S. Tanabe;M. Tsujikawa;K. Kondo;Tomofumi Yamaguchi
小脑经颅直流电刺激（ctDCS）通过小脑脑抑制（CBI）调节初级运动皮层（M1），影响人类的运动控制。然而，ctDCS对运动控制的影响是不一致的，因为对ctDCS期间发生的M1兴奋性的实时变化的不完全理解，ctDCS决定了小脑调节下的运动输出。本研究调查了健康个体ctDCS期间皮质脊髓兴奋性和运动控制的变化。总共有37名健康人参加了三个独立的实验。在休息条件或捏力跟踪任务期间，将ctDCS（2 mA）施加于小脑半球。在ctDCS之前、期间和之后评估运动诱发电位（MEP）振幅和F波，并在ctDCS之前和期间评估捏力控制。在刺激开始后13 min，MEP振幅在阳极ctDCS期间显著降低，而F波没有改变。在阴极和假ctDCS条件下，没有观察到MEP振幅的显着变化。MEP幅度下降，在阳极ctDCS与捏力跟踪任务相结合时，和捏力控制受损，在阳极ctDCS相对于假ctDCS。所有ctDCS条件前后MEP幅度均无显著变化。运动皮层兴奋性被抑制在阳极ctDCS，运动控制是不熟练的阳极ctDCS时，结合运动任务在健康个体。我们的研究结果提供了一个基本的理解ctDCS神经康复的临床应用。
Cerebellar transcranial direct current stimulation (ctDCS) modulates the primary motor cortex (M1) via cerebellar brain inhibition (CBI), which affects motor control in humans. However, the effects of ctDCS on motor control are inconsistent because of an incomplete understanding of the real-time changes in the M1 excitability that occur during ctDCS, which determines motor output under regulation by the cerebellum. This study investigated changes in corticospinal excitability and motor control during ctDCS in healthy individuals. In total, 37 healthy individuals participated in three separate experiments. ctDCS (2 mA) was applied to the cerebellar hemisphere during the rest condition or a pinch force–tracking task. Motor-evoked potential (MEP) amplitude and the F-wave were assessed before, during, and after ctDCS, and pinch force control was assessed before and during ctDCS. The MEP amplitudes were significantly decreased during anodal ctDCS from 13 min after the onset of stimulation, whereas the F-wave was not changed. No significant changes in MEP amplitudes were observed during cathodal and sham ctDCS conditions. The MEP amplitudes were decreased during anodal ctDCS when combined with the pinch force–tracking task, and pinch force control was impaired during anodal ctDCS relative to sham ctDCS. The MEP amplitudes were not significantly changed before and after all ctDCS conditions. Motor cortical excitability was suppressed during anodal ctDCS, and motor control was unskilled during anodal ctDCS when combined with a motor task in healthy individuals. Our findings provided a basic understanding of the clinical application of ctDCS to neurorehabilitation.