Low-frequency repetitive transcranial magnetic stimulation suppresses specific excitatory circuits in the human motor cortex
Low-frequency repetitive transcranial magnetic stimulation suppresses specific excitatory circuits in the human motor cortex
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DOI：
10.1113/jphysiol.2008.159558
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发表时间：
2008-09-15
影响因子：
5.5
通讯作者：
Rothwell, J. C.
中科院分区：
文献类型：
--
作者：
Di Lazzaro, V.;Pilato, F.;Rothwell, J. C.
以往的研究表明，低频重复经颅磁刺激(RTMS)可抑制单脉冲TMS诱发的运动诱发电位(MEPs)。本论文的目的是研究rTMS产生MEP幅度抑制的中枢神经系统水平。我们记录了5名清醒受试者在1 HzrTMS前后由运动皮质单脉冲TMS诱发的皮质脊髓抽动，这些受试者在颈椎硬膜外间隙植入电极以控制疼痛。其中一名患者患有帕金森氏症，正在接受药物研究。重复TMS显著抑制后期I波的波幅，并降低伴随记录的MEP的波幅。RTMS对最早的I波无明显影响。结果表明，1 HzrTMS可降低后期下降波的波幅，这与1 HzrTMS对MEP影响的皮层来源一致。
Previous studies have shown that low-frequency repetitive transcranial magnetic stimulation (rTMS) suppresses motor-evoked potentials (MEPs) evoked by single pulse TMS. The aim of the present paper was to investigate the central nervous system level at which rTMS produces a suppression of MEP amplitude. We recorded corticospinal volleys evoked by single pulse TMS of the motor cortex before and after 1 Hz rTMS in five conscious subjects who had an electrode implanted in the cervical epidural space for the control of pain. One of the patients had Parkinson's disease and was studied on medication. Repetitive TMS significantly suppressed the amplitude of later I-waves, and reduced the amplitude of concomitantly recorded MEPs. The earliest I-wave was not significantly modified by rTMS. The present results show that 1 Hz rTMS may decrease the amplitude of later descending waves, consistent with a cortical origin of the effect of 1 Hz rTMS on MEPs.