Biomaterials Advances in Patches for Congenital Heart Defect Repair
Biomaterials Advances in Patches for Congenital Heart Defect Repair
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DOI：
10.1007/s12265-011-9289-8
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发表时间：
2011-10-01
影响因子：
3.4
通讯作者：
Jacot, Jeffrey G.
中科院分区：
文献类型：
--
作者：
Pok, Seokwon;Jacot, Jeffrey G.
本文就组织工程支架材料在小儿心脏组织工程中的应用现状及新型候选材料作一综述。不同类型生物材料的概述包括天然衍生和合成聚合物及其生物学、物理学和生物力学特性，可用作先天性心脏缺损手术重建的补片或挡板。重点介绍了复合生物材料的应用和特点，以及它们作为心脏支架的各自特点。目前，已经引入了广泛的生物材料用于复杂先天性心脏缺陷的心血管重建。然而，工程组织移植仍然存在许多剩余的挑战。
This article reviews current applications and novel candidate biomaterials for use as tissue-engineered scaffolds in pediatric cardiac tissue engineering. This overview of different types of biomaterials includes naturally derived and synthetic polymers and their biological, physical, and biomechanical properties for the use as a patch or baffle for surgical reconstruction of congenital heart defects. Applications and characteristics of composite biomaterials are highlighted with their respective feasibilities in use as cardiac scaffolds. Currently, a wide range of biomaterials has been introduced for cardiovascular reconstruction for complex congenital cardiac defects. However, there are still many remaining challenges for engineered tissue implantations.