Regulation of intestinal homeostasis by dendritic cells
Regulation of intestinal homeostasis by dendritic cells
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DOI：
10.1111/j.0105-2896.2009.00872.x
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发表时间：
2010-03
影响因子：
8.7
通讯作者：
H. Tezuka;T. Ohteki
中科院分区：
文献类型：
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作者：
H. Tezuka;T. Ohteki
摘要：健康的肠道由共生菌群、上皮层和肠道相关淋巴组织 (GALT) 组成。 GALT 需要对共生抗原和饮食抗原反应低下，同时具有检测和攻击病原体的能力。越来越多的证据表明，树突状细胞 (DC) 在处理这种矛盾情况和维持肠道复杂的稳态方面发挥着不可或缺的作用，其中包括诱导免疫球蛋白 A (IgA) 的合成。这篇综述概述了共生菌群、上皮层和 GALT 在粘膜稳态和炎症条件中的作用，并强调了我们在了解 DC 如何参与肠道 IgA 合成方面的最新进展。
Summary: The healthy gut consists of the commensal flora, the epithelial layer, and the gut‐associated lymphoid tissues (GALT). The GALT need to be hyporesponsive to commensal and dietary antigens while possessing the capacity to detect and attack pathogens. Accumulating evidence suggests that dendritic cells (DCs) play integral roles in managing this paradoxical situation and maintaining the complex homeostasis in the gut, which includes the induction of immunoglobulin A (IgA) synthesis. This review outlines the roles of the commensal flora, epithelial layer, and GALT in mucosal homeostasis and inflammatory conditions and highlights recent progress in our understanding of how DCs are involved in IgA synthesis in the gut.