The relationship between histopathological features of progressive supranuclear palsy and disease duration
The relationship between histopathological features of progressive supranuclear palsy and disease duration
复制标题
DOI：
10.1016/j.parkreldis.2005.08.007
复制
发表时间：
2006-01-01
影响因子：
4.1
通讯作者：
Dickson, DW
中科院分区：
文献类型：
--
作者：
Josephs, KA;Mandrekar, JN;Dickson, DW
进行性核上性麻痹（PSP）是一种独特的临床病理实体，其特征是神经元缠结、簇状星形胶质细胞、线状物和少突胶质细胞卷曲体。这四种病变以不同的密度分布在皮层下和脑干结构中。没有关于PSP中疾病持续时间与病变负荷严重程度关系的数据。我们报告的半定量数据的分析结果，收集的一部分，诊断评估的97例“纯”PSP，提交给社会的PSP脑银行。令人惊讶的是，数据表明，在PSP中，随着疾病持续时间的增加，少突胶质细胞tau负荷减少。(c)2005爱思唯尔有限公司保留所有权利。
Progressive supranuclear palsy (PSP) is a distinct clinicopathological entity characterized by neurofibrillary tangles, tufted astrocytes, threads and oligodendroglial coiled bodies. These four lesions are distributed in varying densities throughout subcortical and brainstem structures. There is no data regarding the relationship of disease duration to lesion burden severity in PSP. We report the results of analysis of semiquantitative data collected as part of the diagnostic evaluation on 97 cases of 'pure' PSP, submitted to the Society of PSP Brain Bank. Surprisingly, the data suggests that in PSP as duration of illness increases there is a decrease in oligodendroglial tau burden. (c) 2005 Elsevier Ltd. All rights reserved.