Distinctive properties of metastasis-initiating cells.
Distinctive properties of metastasis-initiating cells.
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DOI：
10.1101/gad.277681.116
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发表时间：
2016-04-15
影响因子：
10.5
通讯作者：
Kang Y
中科院分区：
文献类型：
--
作者：
Celià-Terrassa T;Kang Y
在转移过程中的巨大的磨损率暗示了一个罕见的和独特的群体的转移起始细胞（MIC）的存在。在这篇综述中，Celià-特拉萨和康总结了MIC的主要肿瘤内在标志及其与外部环境的动态相互作用，以显示其转移形成活性，并讨论了在癌症治疗中靶向MIC的可能策略。已知原发性肿瘤不断地脱落大量癌细胞进入全身性扩散，但这些细胞中只有一小部分能够形成明显的转移。在转移过程中的巨大的磨损率暗示了一个罕见的和独特的群体的转移起始细胞（MIC）的存在。MIC具有可能起源于原发性肿瘤但在播散和定殖期间继续进化的有利特性，包括细胞可塑性、代谢重编程、进入和退出休眠的能力、对细胞凋亡的抗性、免疫逃避以及与其他肿瘤和基质细胞的共选择。更好地了解MIC的分子和细胞特征将有助于开发和部署新的治疗策略。
The tremendous rate of attrition during the process of metastasis implicates the existence of a rare and unique population of metastasis-initiating cells (MICs). In this review, Celià-Terrassa and Kang summarize the main tumor-intrinsic hallmarks of MICs and their dynamic interactions with the extrinsic environment to manifest their metastasis-forming activities and discuss the possible strategy of targeting MICs in cancer therapeutics. Primary tumors are known to constantly shed a large number of cancer cells into systemic dissemination, yet only a tiny fraction of these cells is capable of forming overt metastases. The tremendous rate of attrition during the process of metastasis implicates the existence of a rare and unique population of metastasis-initiating cells (MICs). MICs possess advantageous traits that may originate in the primary tumor but continue to evolve during dissemination and colonization, including cellular plasticity, metabolic reprogramming, the ability to enter and exit dormancy, resistance to apoptosis, immune evasion, and co-option of other tumor and stromal cells. Better understanding of the molecular and cellular hallmarks of MICs will facilitate the development and deployment of novel therapeutic strategies.