Drug prescriptions in French pregnant women between 2015 and 2016: A study in the EGB database
Drug prescriptions in French pregnant women between 2015 and 2016: A study in the EGB database
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DOI：
10.1016/j.therap.2020.07.002
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发表时间：
2021-05-29
期刊：
影响因子：
2.6
通讯作者：
Lacroix, Isabelle
中科院分区：
文献类型：
--
作者：
Araujo, Melanie;Hurault-Delarue, Caroline;Lacroix, Isabelle
目的。-描述法国孕妇的药物处方，并确定致畸和对胎儿有毒性的药物处方。-这项研究使用了法国国家健康数据库Echantillon Generaliste des Benefits(Egb)的数据，该数据库包括第119名法国人口。我们的研究人群包括所有在EGB登记并在2015至2016年间有妊娠结局的10岁至60岁的孕妇。根据怀孕三个月的情况，每年收集和描述在怀孕期间和前三个月开给妇女的处方和分发的药物。对主要致畸药物或胎儿毒性药物的处方进行了描述。-我们确认了18,279例怀孕。其中，93%的孕妇在孕期接受过药物处方和配药，平均用药次数为7.4+/-5.5种。“消化道与代谢”(75.4%)、“神经系统”(64.0%)和“血液及造血器官”(58.7%)是孕妇最常使用的课程。使用频率最高的5种药物是扑热息痛(60.6%)、铁(49.2%)、叶酸(45.6%)、间苯三酚(44.0%)和秋水仙醇(41.4%)。最常见的处方药包括一些在怀孕期间尚未经过严格评估的药物。观察非甾体类抗炎药、维甲酸等致畸药物或胎儿毒性药物的处方和配伍。给孕妇开丙戊酸的处方已变得极为罕见。-这项描述性研究表明，在法国，许多药物被开给孕妇并分发给她们。这些药物包括已被证实具有致畸或胎儿毒性作用的药物，以及许多尚未在怀孕期间进行全面评估的药物。(C)2020年法国药理学和治疗学研究所。爱思唯尔·马森公司出版。版权所有。
Purpose. - To describe drug prescriptions in pregnant women in France and to identify teratogenic and fetotoxic drug prescriptions.Methods. - This study was carried out using data from Echantillon Generaliste des Beneficiaires (EGB), a French national health database which includes 1197th of the French population. Our study population included all pregnant women, aged 10 to 60, who were registered in the EGB and had a pregnancy outcome between 2015 and 2016. Drugs prescribed and dispensed to women during pregnancy and the 3 months before, were collected and described for each year and according to pregnancy trimesters. Prescriptions of major teratogen or fetotoxic drugs were described.Results. - We identified 18,279 pregnancies. Among them, 93% received drug prescriptions and dispensations during pregnancy with an average of 7.4 +/- 5.5 different drugs. "Alimentary tract and metabolism (75.4%)", "nervous system (64.0%)" and "blood and blood forming organs (58.7%)" classes were the most frequently prescribed to pregnant women. The 5 most frequently prescribed drugs were paracetamol (60.6%), iron (49.2%), folic acid (45.6%), phloroglucinol (44.0%) and colecalciferol (41.4%). The most commonly prescribed drugs included some that have not yet been welt evaluated in pregnancy. Prescriptions and dispensations of teratogenic or fetotoxic drugs, as Non-Steroidal Anti-Inflammatory Drugs and retinoids were observed. Valproic acid prescriptions to pregnant women have become extremely rare.Conclusion. - This descriptive study demonstrates that numerous drugs are prescribed and dispensed to pregnant women in France. These include drugs with a proven teratogenic or fetotoxic effect and many drugs that have not yet been welt evaluated in pregnancy. (C) 2020 Societe francaise de pharmacologie et de therapeutique. Published by Elsevier Masson SAS. All rights reserved.