Molecular biology of otosclerosis.
Molecular biology of otosclerosis.
复制标题
耳硬化症的分子生物学。
DOI：
10.1159/000098674
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发表时间：
2007
影响因子：
--
通讯作者：
Kristiansen,ArthurG
中科院分区：
文献类型：
--
作者：
McKenna,MichaelJ;Kristiansen,ArthurG
Otosclerosis is a bone disease of the human otic capsule, which is among the most common causes of acquired hearing loss. The pathologic process is characterized by a wave of abnormal bone remodeling in specific sites of predilection within the endochondral layer of the temporal bone. Although the cause of otosclerosis remains uncertain, there is a clear genetic predisposition with half of all cases occurring in families with more than one affected member. There is also compelling evidence that measles virus may play a role in some cases. Ultimately, how genetic factors and viral infection result in otosclerosis must be explained by effects on the molecular factors that control bone remodeling.
