Dopamine D-1 receptor-mediated facilitation of GABAergic neurotransmission in the rat strioentopeduncular pathway and its modulation by adenosine A(1) receptor-mediated mechanisms
Dopamine D-1 receptor-mediated facilitation of GABAergic neurotransmission in the rat strioentopeduncular pathway and its modulation by adenosine A(1) receptor-mediated mechanisms
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DOI：
10.1111/j.1460-9568.1996.tb01617.x
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发表时间：
1996-07-01
影响因子：
3.4
通讯作者：
Fuxe, K
中科院分区：
文献类型：
--
作者：
Ferre, S;OConnor, WT;Fuxe, K
通过使用体内微透析，发现纹状体多巴胺D-1受体的主要功能之一是选择性地促进“直接”纹状体脚通路中的GABA能神经传递。D-1受体定位于脚内核也被发现，以促进GABA的释放。然而，从体内微透析，在体内电化学，免疫组织化学和共聚焦激光显微镜得到的结果表明，内脚D-1受体只能在药理学条件下被激活。腺苷A（1）受体被发现拮抗调节D-1介导的调节纹状体脚通路。此外，原位杂交显示D-1和A（1）受体共定位于中型纹状体神经元。这些结果表明，纹状体脚神经元是脑中腺苷-多巴胺相互作用的主要场所。
By using in vivo microdialysis it was found that one of the main functions of striatal dopamine D-1 receptors is to selectively facilitate GABAergic neurotransmission in the 'direct' strioentopeduncular pathway. D-1 receptors localized in the entopeduncular nucleus were also found to facilitate GABA release. However, results obtained from in vivo microdialysis, in vivo electrochemistry, immunohistochemistry and confocal laser microscopy suggested that entopeduncular D-1 receptors could only be activated under pharmacological conditions. Adenosine A(1) receptors were found to antagonistically modulate the D-1-mediated regulation of the strioentopeduncular pathway. Furthermore, using in situ hybridization D-1 and A(1) receptors were shown to be colocalized in medium-sized striatal neurons, These results show that the strioentopeduncular neuron is a main locus for adenosine-dopamine interactions in the brain.