Depression in Parkinson's disease: Convergence from voxel-based morphometry and functional magnetic resonance imaging in the limbic thalamus
Depression in Parkinson's disease: Convergence from voxel-based morphometry and functional magnetic resonance imaging in the limbic thalamus
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DOI：
10.1016/j.neuroimage.2009.04.059
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发表时间：
2009-08-15
期刊：
影响因子：
5.7
通讯作者：
Amaro, Edson, Jr.
中科院分区：
文献类型：
--
作者：
Cardoso, Ellison Fernando;Maia, Fernanda Martins;Amaro, Edson, Jr.
抑郁症是帕金森病（PD）中最常见的精神障碍。尽管有证据表明PD患者的抑郁与疾病的退行性过程有关，但需要进一步的研究来更好地了解这类患者抑郁的神经基础。为了研究PD患者抑郁背后的神经元改变，我们研究了36例特发性PD患者。这些患者中有20人被诊断为重度抑郁症，16人没有。根据统一帕金森病评定量表（UPDRS）对两组PD运动严重程度进行匹配。首先，我们使用事件相关的参数化情绪感知范式和测试重测设计进行了功能磁共振成像（fMRI）。我们的研究结果显示，与没有抑郁症的PD患者相比，抑郁症患者的左中背丘脑和内侧前额叶皮层的激活减少。基于这些结果和先前研究中发现的MD丘脑神经元数量增加，我们进行了感兴趣区域（ROI）引导的基于体素的形态测量（VBM）研究，比较了丘脑体积。我们的结果显示双侧丘脑中背核体积增加。中背丘脑的会聚性形态变化和功能性情绪加工突出了边缘丘脑在PD抑郁症中的重要性。此外，这些数据支持神经退行性改变和情绪调节之间的联系。(C) 2009爱思唯尔公司版权所有。
Depression is the most frequent psychiatric disorder in Parkinson's disease (PD). Although evidence Suggests that depression in PD is related to the degenerative process that underlies the disease, further studies are necessary to better understand the neural basis of depression in this population of patients. In order to investigate neuronal alterations underlying the depression in PD, we studied thirty-six patients with idiopathic PD. Twenty of these patients had the diagnosis of major depression disorder and sixteen did not. The two groups were matched for PD motor severity according to Unified Parkinson Disease Rating Scale (UPDRS). First we conducted a functional magnetic resonance imaging (fMRI) using an event-related parametric emotional perception paradigm with test retest design. Our results showed decreased activation in the left mediodorsal (MD) thalamus and in medial prefrontall cortex in PD patients with depression compared to those without depression. Based upon these results and the increased neuron count in MD thalamus found in previous studies, we conducted a region of interest (ROI) guided voxel-based morphometry (VBM) study comparing the thalamic volume. Our results showed an increased volume in mediodorsal thalamic nuclei bilaterally. Converging morphological changes and functional emotional processing in mediodorsal thalamus highlight the importance of limbic thalamus in PD depression. In addition this data supports the link between neurodegenerative alterations and mood regulation. (C) 2009 Elsevier Inc. All rights reserved.