Enzymes in cancer.
Enzymes in cancer.
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癌症中的酶。
DOI：
10.1093/clinchem/19.1.10
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发表时间：
1973
影响因子：
9.3
通讯作者：
M. Schwartz
中科院分区：
文献类型：
--
作者：
M. Schwartz
自从瓦尔堡和他的同事在1924年报道癌组织比正常组织表现出更大的有氧糖酵解速率以来，已经有许多努力来定义癌组织中的酶缺陷。已经尝试在癌症的诊断中和在疾病的过程中使用酶测定。本文综述了器官特异性酶（淀粉酶、磷酸水解酶等）在这方面的作用。以及更普遍的糖酵解酶。有用的测定同工酶在血清中，以及在组织中的癌症患者，讨论和作用的酶在化疗中考虑
Since Warburg and his associates reported in 1924 that cancer tissue exhibits a greater rate of aerobic glycolysis than normal tissue, there have been numerous efforts to define enzymatic defects in cancer tissue. Attempts have been made to use enzyme assays in the diagnosis of cancer and in following the course of the disease. This review considers in this regard the role of organ-specific enzymes (amylase, phosphohydrolases, etc.) as well as the more ubiquitous glycolytic enzymes. The usefulness of the assay of isoenzymes in serum, as well as in tissue of cancer patients, is discussed and the role of enzymes in chemotherapy considered