Anxiety disorders among patients with co-occurring bipolar and substance use disorders
Anxiety disorders among patients with co-occurring bipolar and substance use disorders
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DOI：
10.1016/j.drugalcdep.2005.04.003
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发表时间：
2005-11-01
影响因子：
4.2
通讯作者：
Weiss, RD
中科院分区：
文献类型：
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作者：
Kolodziej, ME;Griffin, ML;Weiss, RD
双相情感障碍和物质使用障碍是已知的共同发生频繁，但有限的注意力已经支付给焦虑症，可能伴随着这种双重诊断。因此，我们检查了目前诊断为双相情感障碍和物质使用障碍的寻求治疗的患者中焦虑障碍的患病率和性质，并调查了焦虑障碍和物质使用之间的关系。在90名被诊断为双相情感障碍I（它= 75，78%）或11名（n = 15，22%）的参与者中，43名（48%）患有终身焦虑症，其中创伤后应激障碍（PTSD）最常见（它= 21，23%）。我们发现，那些患有PTSD的人，而不是其他焦虑症的人，在更早的年龄开始使用药物，并且比那些没有PTSD的人有更多的终身物质使用障碍，特别是可卡因和安非他明使用障碍。进一步的检查显示：（1）大多数PTSD患者是女性，（2）性虐待是最常报告的指数创伤，（3）最早指数创伤的平均年龄发生在开始使用药物的平均年龄之前。我们的研究结果指出了进一步调查双重诊断为双相情感障碍和物质使用障碍的创伤史的重要性。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Bipolar and substance use disorders are known to co-occur frequently, but limited attention has been paid to anxiety disorders that may accompany this dual diagnosis. Therefore, we examined the prevalence and nature of anxiety disorders among treatment-seeking patients diagnosed with current bipolar and substance use disorders, and investigated the association between anxiety disorders and substance use. Among 90 participants diagnosed with bipolar disorder I (it = 75, 78%) or 11 (n = 15, 22%), 43 (48%) had a lifetime anxiety disorder, with post-traumatic stress disorder (PTSD) occurring most frequently (it = 21, 23%). We found that those with PTSD, but not with the other anxiety disorders assessed, began using drugs at an earlier age and had more lifetime substance use disorders, particularly cocaine and amphetamine use disorders, than those without PTSD. Further examination revealed that (1) most participants with PTSD were women, (2) sexual abuse was the most frequently reported index trauma, and (3) the mean age of the earliest index trauma occurred before the mean age of initiation of drug use. Our findings point to the importance of further investigating the ramifications of a trauma history among those who are dually diagnosed with bipolar and substance use disorders. (c) 2005 Elsevier Ireland Ltd. All rights reserved.