Cross-Link-Governed Dynamics of Biopolymer Networks
Cross-Link-Governed Dynamics of Biopolymer Networks
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DOI：
10.1103/physrevlett.105.238101
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发表时间：
2010-11-30
影响因子：
8.6
通讯作者：
MacKintosh, Frederick C.
中科院分区：
文献类型：
--
作者：
Broedersz, Chase P.;Depken, Martin;MacKintosh, Frederick C.
最近的实验表明，由瞬时连接物蛋白交联的刚性生物聚合物网络表现出复杂的应力松弛，使网络能够长时间流动。我们提出了这种网络中由交联链控制的动力学模型。我们发现，交联剂解离的单个微观时间尺度导致了广泛的宏观弛豫时间和与低频omega(1/2)相似的剪切模数G。这个模型定量地描述了在40多年的频率上与α-肌动蛋白-4交联的肌动蛋白网络的测量流变性。
Recent experiments show that networks of stiff biopolymers cross-linked by transient linker proteins exhibit complex stress relaxation, enabling network flow at long times. We present a model for the dynamics controlled by cross-links in such networks. We show that a single microscopic time scale for cross-linker unbinding leads to a broad spectrum of macroscopic relaxation times and a shear modulus G similar to omega(1/2) for low frequencies omega. This model quantitatively describes the measured rheology of actin networks cross-linked with alpha-actinin-4 over more than four decades in frequency.