Association between exposure to ambient air pollution and renal function in Korean adults.
Association between exposure to ambient air pollution and renal function in Korean adults.
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DOI：
10.1186/s40557-018-0226-z
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发表时间：
2018
影响因子：
1.3
通讯作者：
Min KB
中科院分区：
文献类型：
--
作者：
Kim HJ;Min JY;Seo YS;Min KB
环境空气污染对许多疾病都有负面影响，如心血管疾病和呼吸系统疾病。最近的研究报告了空气污染与肾功能之间的关系，但结果仅限于暴露在颗粒物(PM)中。这项研究旨在确定各种空气污染物与韩国成年人肾功能之间的关系。对24407名成年人的全国调查数据进行了分析。我们计算了每个个体的估计肾小球滤过率(EGFR)来评估他们的肾功能，并用它来对慢性肾脏疾病(CKD)患者进行分类。为了评估暴露在环境空气污染中，我们使用了四种环境空气污染物的年平均浓度：空气动力学直径为≤10μm(PM10)的PM、二氧化氮(NO2)、二氧化硫(SO2)和一氧化碳(CO)。在所有的统计调整模型中，我们发现空气污染物PM_(10)、NO_2和EGFR之间存在显著的负相关关系(所有p <； 均为0.05)。在全协变量模型中，PM10和NO2年平均浓度的四分位数范围内的增加分别与EGFR水平的下降相关，分别为0.46(95%CI = − 0.87，− 0.04)和0.85(95%CI = − 1.40，− 0.30)。在未经调整的模型中，有三种环境空气污染物与慢性肾脏病风险的增加显著相关(p <； 0.0001)，但在调整协变量后，所有显著的相关性都消失了(所有p &t； 0.05)。在韩国成年人中，暴露于PM10和NO2与EGFR水平的降低显著相关，但与慢性肾脏病无关。
Ambient air pollution has a negative effect on many diseases, such as cardiovascular and respiratory diseases. Recent studies have reported a relationship between air pollution and renal function, but the results were limited to exposure to particulate matter (PM). This study was to identify associations between various air pollutants and renal function among Korean adults. Nationwide survey data for a total of 24,407 adults were analyzed. We calculated the estimated glomerular filtration rate (eGFR) for each individual to assess their renal function and used this to categorize those with chronic kidney disease (CKD). To evaluate exposure to ambient air pollution, we used the annual mean concentrations of four ambient air pollutants: PM with an aerodynamic diameter ≤ 10 μm (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO). We identified significant inverse relationships between the air pollutants PM10 and NO2 and eGFR in all statistical adjustment models (all p < 0.05). In the full covariate model, interquartile range increases in the annual mean concentrations of PM10 and NO2 were associated with decreases in eGFR levels of 0.46 (95% CI = − 0.87, − 0.04) and 0.85 (95% CI = − 1.40, − 0.30), respectively. Three of the ambient air pollutants were significantly related to an increased risk of CKD in the unadjusted model (p < 0.0001), but all significant associations disappeared after adjusting for covariates (all p > 0.05). Exposures to PM10 and NO2 were significantly associated with decreases in eGFR levels, but not CKD, in Korean adults.