Amine-catalyzed direct Diels-Alder reactions of α,β-unsaturated ketones with nitro olefins
Amine-catalyzed direct Diels-Alder reactions of α,β-unsaturated ketones with nitro olefins
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DOI：
10.1016/s0040-4039(02)00686-x
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发表时间：
2002-05-20
影响因子：
1.8
通讯作者：
Barbas, CF
中科院分区：
文献类型：
--
作者：
Thayumanavan, R;Dhevalapally, B;Barbas, CF
氨基催化的-、-不饱和酮与亲二酚类化合物的Diels Alder反应已被开发。(S)-1-（2-吡咯烷基甲基）吡咯烷或l -脯氨酸均可催化2-氨基-1,3-二烯的原位生成和反应，一步生成收率高达87%的环己酮衍生物，对映选择性适中。(C) 2002年Elsevier Science Ltd.出版
Amine-catalyzed Diels Alder reactions of alpha,beta-unsaturated ketones with dienophiles have been developed. Either (S)-1-(2-pyrrolidinylmethyl)pyrrolidine or L-proline catalyzed the in situ-generation and reaction of 2-amino-1,3-dienes to provide cyclohexanone derivatives in good yield (up to 87%) in one step with modest enantioselectivity. (C) 2002 Published by Elsevier Science Ltd.