Roles of Rab family small G proteins in formation of the apical junctional complex in epithelial cells
Roles of Rab family small G proteins in formation of the apical junctional complex in epithelial cells
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Rab家族小G蛋白在上皮细胞顶端连接复合物形成中的作用
DOI：
10.1007/978-3-319-14463-4_15
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
T.
中科院分区：
文献类型：
--
作者：
Sakane;A. and Sasaki;T.
上皮组织的形成和功能需要单层膜的组织，这是通过顶端连接复合体(AJC)介导的。AJC由一组不同的关键因子组成：黏附分子包括E-钙粘蛋白、claudins和occludin；支持顶膜和基底侧膜的组织和功能的极性蛋白质；以及支持黏附、囊泡运输、肌动蛋白细胞骨架重排和膜支架的蛋白质。这些蛋白质形成了一个动态的合作网络，参与了对AJC的高度精细的调控。一些证据表明，Rab家族的小G蛋白在调节上皮细胞顶端连接中起重要作用，这些连接的组装和拆解可以由定位于内体或顶端连接的Rab蛋白驱动。本文综述了Rab蛋白对AJC功能的影响，重点介绍了包含Rab13和JRAb/Mical-L2(与CASL-like 2相互作用的连接性Rab13结合蛋白/分子)的复合体在调控上皮尖连接中的作用。
Epithelial tissue formation and function require organization of monolayer sheets, which is mediated through the apical junctional complex (AJC). The AJC comprises a diverse set of key factors: adhesion molecules including E-cadherin, claudins, and occludin; polarity proteins that support organization and function of apical and basolateral membranes; and proteins that support adhesion, vesicle transport, actin cytoskeletal rearrangement, and membrane scaffolds. These proteins form a dynamic cooperative network that is engaged in the highly elaborate regulation of AJC. Several lines of evidence indicate that Rab family small G proteins play important roles in the regulation of epithelial apical junctions and that the assembly and disassembly of these junctions can be driven by Rab proteins localized at either endosomes or apical junctions. In this review, we provide an overview of the influence of Rab proteins on AJC functions, focusing especially on the role of the complex containing Rab13 and JRAB/MICAL-L2 (junctional Rab13-binding protein/molecule interacting with CasL-like 2) in the regulation of epithelial apical junctions.