Auditory Spatial Discrimination and the Mismatch Negativity Response in Hearing-Impaired Individuals.
Auditory Spatial Discrimination and the Mismatch Negativity Response in Hearing-Impaired Individuals.
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听力障碍者的听觉空间歧视和不匹配的消极反应
DOI：
10.1371/journal.pone.0136299
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Chen G
中科院分区：
文献类型：
--
作者：
Cai Y;Zheng Y;Liang M;Zhao F;Yu G;Liu Y;Chen Y;Chen G
本研究的目的是研究不同听力状况的听力受损(HI)个体在中线和侧位辨别空间听源的能力，并通过测量最小可听角(MAA)和失配负波(MMN)反应来探讨可能的中枢加工机制。对12例听力正常(NH)受试者和36例感音神经性耳聋患者进行左/右0°、45°和90°位MAA测定，其中对称性听力损失(SHL)12例，非对称性听力损失(AHL)24例，其中左侧听力损失(UHLL)12例，右侧听力损失(UHLR)12例。此外，采用128电极脑电图仪记录了60例患者(UHL20例，UHL20例，SHL20例)和20例NH患者的MMN反应。结果显示，NH组的MAA阈值显著低于HI组。此外，在NH和SHL组中，正中位置的MAA阈值明显小于侧位。而AHL组患侧90°位的MAA阈值明显小于其他部位的MAA阈值。与NH组相比，HI组MMN波幅显著降低，潜伏期明显延长。此外，在UHL组和NH组中，患侧90°位发出的声音可被对侧激活。这些发现表明，在不同的听力条件下，中线和侧线位置的空间辨别能力存在显著差异。MMN波幅的降低和潜伏期的延长，以及听觉半球两侧对称的皮质激活，可能表明与HI患者行为空间辨别能力差有关的皮质代偿性变化。
The aims of the present study were to investigate the ability of hearing-impaired (HI) individuals with different binaural hearing conditions to discriminate spatial auditory-sources at the midline and lateral positions, and to explore the possible central processing mechanisms by measuring the minimal audible angle (MAA) and mismatch negativity (MMN) response. To measure MAA at the left/right 0°, 45° and 90° positions, 12 normal-hearing (NH) participants and 36 patients with sensorineural hearing loss, which included 12 patients with symmetrical hearing loss (SHL) and 24 patients with asymmetrical hearing loss (AHL) [12 with unilateral hearing loss on the left (UHLL) and 12 with unilateral hearing loss on the right (UHLR)] were recruited. In addition, 128-electrode electroencephalography was used to record the MMN response in a separate group of 60 patients (20 UHLL, 20 UHLR and 20 SHL patients) and 20 NH participants. The results showed MAA thresholds of the NH participants to be significantly lower than the HI participants. Also, a significantly smaller MAA threshold was obtained at the midline position than at the lateral position in both NH and SHL groups. However, in the AHL group, MAA threshold for the 90° position on the affected side was significantly smaller than the MMA thresholds obtained at other positions. Significantly reduced amplitudes and prolonged latencies of the MMN were found in the HI groups compared to the NH group. In addition, contralateral activation was found in the UHL group for sounds emanating from the 90° position on the affected side and in the NH group. These findings suggest that the abilities of spatial discrimination at the midline and lateral positions vary significantly in different hearing conditions. A reduced MMN amplitude and prolonged latency together with bilaterally symmetrical cortical activations over the auditory hemispheres indicate possible cortical compensatory changes associated with poor behavioral spatial discrimination in individuals with HI.