Relaxin signaling in uterine fibroids.
Relaxin signaling in uterine fibroids.
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子宫肌瘤中的松弛素信号传导。
DOI：
10.1111/j.1749-6632.2008.03803.x
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发表时间：
2009
影响因子：
5.2
通讯作者：
Agoulnik,AlexanderI
中科院分区：
文献类型：
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作者：
Li,Zhen;Burzawa,JenniferK;Troung,Anne;Feng,Shu;Agoulnik,IrinaU;Tong,Xiaowen;Anderson,MatthewL;Kovanci,Ertug;Rajkovic,Aleksandar;Agoulnik,AlexanderI
子宫肌瘤是女性生殖器官最常见的肿瘤。分析松弛素信号在平滑肌瘤发生中的作用。我们使用了23对匹配的平滑肌瘤和正常子宫肌层样本来比较松弛素家族肽受体RXFP 1和RXFP 2、小窝蛋白1、结蛋白和类固醇受体及其辅因子NCOR 1和NCOR 2的表达。通过定量逆转录-PCR评估，RXFP 1的表达在纤维瘤组织中下调。松弛素或胰岛素样肽3处理抑制转化生长因子β诱导的大鼠平滑肌瘤ELT-3细胞中SMAD 2的体外磷酸化，表明松弛素可能参与平滑肌瘤的病因学。
Uterine fibroid is the most common tumor of female reproductive organs. The role of relaxin signaling in leiomyoma development was analyzed. We used 23 matched pairs of leiomyoma and normal myometrium samples to compare the expression of relaxin family peptide receptors RXFP1 and RXFP2, caveolin 1, desmin, and steroid receptors and their cofactors, NCOR1 and NCOR2. The expression of RXFP1, evaluated by quantitative reverse transcription‐PCR, was downregulated in fibroid tissues. Relaxin or insulin‐like peptide 3 treatment suppressed transforming growth factor β‐induced phosphorylation of SMAD2 in rat leiomyoma ELT‐3 cellsin vitro, suggesting a possible involvement of relaxins in the etiology of leiomyoma.