Compartmental study of T1 and T2 in rat brain and trigeminal nerve in vivo
Compartmental study of T1 and T2 in rat brain and trigeminal nerve in vivo
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DOI：
10.1002/mrm.10060
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发表时间：
2002-02-01
影响因子：
3.3
通讯作者：
Gore, JC
中科院分区：
文献类型：
--
作者：
Does, MD;Gore, JC
使用快速方法获取一系列依赖于 T-1 和 T-2 弛豫时间的图像，在体内研究了大鼠大脑和三叉神经水的综合 T-1-T-2 特征。灰质区域在 T-1 和 T-2 域中仅显示一种信号分量。然而，先前已证明三叉神经表现出三个 T-2 成分，现在发现三叉神经也表现出三个 T-1 成分。这些 T-1 和 T-2 分量之间的相关性通过使用反转恢复制剂独特地滤除三个 T-2 分量中的每一个来证明，如分量 T-1 值所确定。根据之前的工作，假设这三个信号分量中的每一个都源自神经的独特的微观解剖区域。因此，对这些 T-1 成分的了解可能有助于设计识别髓磷脂等组织亚型的存在和量化其体积的新方法。 Magn Reson Med 47:274-283, 2002。(C) 2002 Wiley-Liss, Inc.
The integrated T-1-T-2 characteristics of rat brain and trigeminal nerve water were studied in vivo using a rapid method for acquiring a series of images that depend on T-1 and T-2 relaxation times. Gray matter regions showed only one signal component in both the T-1 and T-2 domains. Trigeminal nerve, however, which has been shown previously to exhibit three T-2 components, was found to also exhibit three T-1 components. The correlations between these T-1 and T-2 components were demonstrated by uniquely filtering out each of the three T-2 components using an inversion-recovery preparation, as determined by the component T-1 values. Based on previous works, it is postulated that each of these three signal components is derived from a unique microanatomical region of the nerve. Knowledge of these T-1 components may thus prove valuable in devising novel methods of identifying the presence and quantifying the volume of tissue subtypes such as myelin. Magn Reson Med 47:274-283, 2002. (C) 2002 Wiley-Liss, Inc.