Low fat adiponectin expression is associated with oxidative stress in nondiabetic humans with chronic kidney disease--impact on plasma adiponectin concentration.
Low fat adiponectin expression is associated with oxidative stress in nondiabetic humans with chronic kidney disease--impact on plasma adiponectin concentration.
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DOI：
10.1152/ajpregu.00745.2006
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发表时间：
2007-07
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影响因子：
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通讯作者：
R. Barazzoni;A. Bernardi;F. Biasia;A. Semolic;A. Bosutti;M. Mucci;F. Dore;M. Zanetti;G. Guarnieri
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文献类型：
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作者：
R. Barazzoni;A. Bernardi;F. Biasia;A. Semolic;A. Bosutti;M. Mucci;F. Dore;M. Zanetti;G. Guarnieri
尽管高血浆脂联素与高代谢和心血管（CV）风险之间存在关联，但在晚期慢性肾脏疾病（CKD）中，最高的脂联素增量保留了CV和代谢保护作用。被动积累可能有利于ckd相关的高脂联素血症，但脂肪组织的潜在额外调节仍不明确。氧化应激（OS）与代谢性和心血管疾病以及CKD相关[从保守治疗（CT）到维持性血液透析（MHD）增加]，并且在实验模型中，OS可以降低脂联素的表达。通过CT （n = 7）或MHD （n = 11）研究CKD患者（4期和5期）的OS（血浆硫代巴比妥酸反应物质：TBARS）、皮下脂肪脂联素mRNA和血浆脂联素。与CT组和对照组（C: n = 6）相比，MHD组TBARS最高，脂联素mRNA最低（P < 0.05），脂肪脂联素蛋白较低（P < 0.05）。MHD组血浆脂联素低于CT组，但均高于C组（P < 0.05）。在肾移植受者（RT: CKD 3期；n = 5）中，正常的TBARS反过来与正常的脂联素mRNA相关（P < 0.05 vs. MHD）。在所有CKD患者（n = 23）中，脂联素mRNA与血浆脂联素浓度呈正相关（P < 0.01）。在所有受试者（n = 29）中，调整血浆c反应蛋白（CRP）或CRP与肌酐后，脂联素mRNA与TBARS呈负相关（P < 0.05）。因此，改变的OS、脂联素表达和血浆浓度代表了MHD中一组新的代谢和心血管危险因素，这些因素在大鼠中被归一化。这些数据表明，1)MHD相关的OS在调节脂联素表达方面发挥了新的作用，2)脂肪组织在促进晚期CKD中循环脂联素方面发挥了新的作用。
In spite of association between high plasma adiponectin and high metabolic and cardiovascular (CV) risk, highest adiponectin increments retain CV and metabolic protective effects in advanced chronic kidney disease (CKD). Passive accumulation can favor CKD-associated hyperadiponectinemia but potential additional regulation by adipose tissue remains undefined. Oxidative stress (OS) is associated with metabolic and CV disease and with CKD [increasing from conservative treatment (CT) to maintenance hemodialysis (MHD)], and OS can reduce adiponectin expression in experimental models. OS (in the form of plasma thiobarbituric acid-reactive substances: TBARS), subcutaneous adipose adiponectin mRNA, and plasma adiponectin were studied in CKD patients (stages 4 and 5) on CT (n = 7) or MHD (n = 11). Compared with CT and controls (C: n = 6) MHD had highest TBARS and lowest adiponectin mRNA (P < 0.05) with lower adipose adiponectin protein (P < 0.05 vs. CT). MHD also had lower plasma adiponectin than CT, although both had higher adiponectin than C (P < 0.05). In renal transplant recipients (RT: CKD stage 3; n = 5) normal TBARS were, in turn, associated with normal adiponectin mRNA (P < 0.05 vs. MHD). In all CKD (n = 23), adiponectin mRNA was associated positively with adiponectin plasma concentration (P < 0.01). In all subjects (n = 29), adiponectin mRNA was related (P < 0.05) negatively with TBARS after adjusting for plasma C-reactive protein (CRP) or CRP and creatinine. Thus altered OS, adiponectin expression, and plasma concentration represent a novel cluster of metabolic and CV risk factors in MHD that are normalized in RT. The data suggest novel roles of 1) MHD-associated OS in modulating adiponectin expression and 2) adipose tissue in contributing to circulating adiponectin in advanced CKD.