Feasibility of Institutional Registry-Based Recruitment for Enrolling Newly Diagnosed Breast Cancer Patients in an Exercise Trial
Feasibility of Institutional Registry-Based Recruitment for Enrolling Newly Diagnosed Breast Cancer Patients in an Exercise Trial
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DOI：
10.1123/jpah.8.7.955
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发表时间：
2011-09-01
影响因子：
3.1
通讯作者：
Irwin, Melinda
中科院分区：
文献类型：
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作者：
Bertram, Lisa A. Cadmus;Chung, Gina;Irwin, Melinda
背景：本研究的目的是确定使用肿瘤登记处招募新诊断的幸存者参加随机对照运动试验的可行性，并讨论与该招募策略相关的问题。方法：使用基于肿瘤登记的快速确定系统将乳腺癌幸存者纳入为期 6 个月的家庭电话管理中度至剧烈强度运动干预或常规护理组。结果：新增确诊病例468例。其中，50 名女性（占接受筛查的女性的 15.4%）参加了这项研究。女性平均在诊断后 11 周被随机分配（SD = 4.8）。百分之六十四的人在开始治疗前或治疗第一周内被随机分配。获得医生同意所需的时间是诊断到随机化潜伏期的主要决定因素。已登记的女性比未登记的女性更有可能是非西班牙裔白人并拥有大学学位 (P < .05)。结论：肿瘤登记处提供了一种在辅助治疗之前或早期招募乳腺癌幸存者的可行方法。诊断后迅速招募幸存者的成功很大程度上取决于快速获得医生同意的能力。需要做出具体努力来抵消可能导致少数群体代表性不足的自我选择效应。
Background: The purpose of this study was to determine the feasibility of using a tumor registry to recruit newly diagnosed survivors into a randomized controlled exercise trial and to discuss issues related to this recruitment strategy. Methods: A tumor registry-based rapid ascertainment system was used to recruit breast cancer survivors into a 6-month home-based, telephone-administered intervention of moderate-to-vigorous intensity exercise or a usual care group. Results: 468 newly diagnosed cases were identified. Of these, 50 women (15.4% of those for which screening calls were made) were enrolled in the study. Women were randomized, on average, 11 weeks after diagnosis (SD = 4.8). Sixty-four percent were randomized before beginning treatment or within the first week of treatment. Time required to obtain physician consent was the primary determinant of diagnosis-to-randomization latency. Enrolled women were more likely than nonenrolled women to be non-Hispanic White and to have a college degree (P < .05). Conclusion: Tumor registries present a feasible means of recruiting breast cancer survivors before or early in adjuvant treatment. The success of recruiting survivors promptly after diagnosis is largely dependent on ability to rapidly obtain physician consent. Specific effort is needed to counteract self-selection effects that may lead to under-representation of minorities.