Formalin induces biphasic activity in C-fibers in the rat
Formalin induces biphasic activity in C-fibers in the rat
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DOI：
10.1016/0304-3940(96)12552-0
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发表时间：
1996-04-12
影响因子：
2.5
通讯作者：
Levine, JD
中科院分区：
文献类型：
--
作者：
McCall, WD;Tanner, KD;Levine, JD
虽然福尔马林试验是一种广泛使用的强直化学性疼痛的行为模型，但对初级传入伤害感受器对福尔马林的反应知之甚少。将福尔马林（2.5%，50 μ l）直接注射到从戊巴比妥麻醉大鼠隐神经分离的单个C纤维的机械感受野中或附近。随着时间的推移，C纤维（n = 29）中的所有n-诱发反应的平均值是双相的。这种对福尔马林的C纤维反应的双相时程与清醒动物的行为反应的双相时程相似，并且与增加的C纤维活性有助于福尔马林试验的第2阶段以及第1阶段中的行为反应的假设相容。
While the formalin test is a widely used behavioral model of tonic chemogenic pain, little is known about the responses of primary afferent nociceptors to formalin. Formalin (2.5%, 50 mu l) was injected either directly in or adjacent to the mechanical receptive fields of single C-fibers isolated from the saphenous nerve of pentobarbital-anesthetized rats. The average form all n-evoked response in C-fibers (n = 29) over time was biphasic. This biphasic time course of the C-fiber response to formalin is similar to that of the behavioral response in the awake animal and is compatible with the hypothesis that increased C-fiber activity contributes to the behavioral response in phase 2, as well as in phase 1 of the formalin test.